MS Sufferer Scott to Undergo Cord Blood Stem-Cell Treatment

Twenty-seven year old Scott from Balby in the UK has suffered from multiple sclerosis most of his life. However, today Scott is on his way to Holland to undergo the first stage of a stem-cell based treatment that he hopes will transform his life and defeat his terminal illness. Unable to feed himself and confined to a wheelchair, Scott hopes the injections will help him walk again.

Scott’s mother, Sue, said: “We know there are no guarantees with this treatment, but we realize it’s the best chance Scott has.”

The treatment involves three days of intense therapy, and patients that decided to undergo the procedure claim their condition significantly improved.

Scott could start to experience therapeutic benefits within months.

In the Dutch city of Eindhoven, Scott is set to receive “aqua tilis” therapy in a clinic today. The procedure requires Scott to sit in a cabin for approximately half an hour while being surrounded by water vapor which will enter his body’s pours, a process which facilitates detoxification and increases the chances of the stem-cell treatment being successful.

Scheduled for tomorrow at a clinic in Rotterdam, Beanlands’ appointment will involve injections of umbilical cord blood stem-cells into his body.

The hope is that the healthy stem-cells will replace the diseased or dysfunctional ones in Scott’s body, and become a new life-long repair system.

The treatment costs £13,000, much of which was raised by Leicester Mercury readers after we first told Scott’s story.

Experimental Procedure Brings Hope to Man

Steve wasn’t wearing a seatbelt. Two of the discs in the cervical region of his spinal cord were shattered. His skull, smashed against the car’s door jam. Steve left the intensive care unit at Christiana Hospital as a tetraplegic, with complete or partial paralysis in all four limbs.

It all happened on Feb. 18, 2001 as he headed home from his relatives house in southeastern Pennsylvania, south on Limestone Road toward Pike Creek. It was just before 4:30 a.m. as he drifted off to sleep and off the road, striking head on into a utility pole causing several power outages in the area.

No one could have predicted what was to happen that night, but Steve’s injuries could have been much worse. Presently he has some strength in his arms, hands and fingers. He can even drive, although in a specialized 2002 Dodge Caravan. Within the 8 months following the accident, he was back at work in Delaware. Steve was a senior motor vehicles technician at the Department of Motor Vehicles in New Castle.

Steve made strides in his progress following the accident, but soon Steve, now 37, may be able to do even more.

At the Hosptial de Egas Moniz in Lisbon, Portugal, Yaros underwent an olfactory mucosa autograph – a type of stem cell surgery. Cell tissue was extracted from the uppermost part of Steve’s nasal cavity and transplanted into his spinal cord. Researchers believe that the transplanted stem cells in this procedure can help repair a damaged spinal cord.

“It seems like these cells have the same potential in terms of forming a variety of cell types, just like embryonic stem cells,” said Jean, an associate professor at Wayne State University Medical School in Detroit.

The operation is not approved by the U.S. Food and Drug Administration, thus facilitating the need for Americans to go outside the country for treatment. At a cost of almost $45,000, 40 individuals from the United States and more than 80 worldwide have undergone the procedure.

Steve would love to be able to walk again, but he has stated that even minor improvement would be worth it. For example, his grip has been so weak that it is difficult for him to get him cash withdrawal card out of the ATM machine.

“I can’t even tear a piece of paper,” he said before leaving for Portugal.

He learned about the stem cell procedure last year from a friend. A few months ago, he flew to the Rehabilitation Institute of Michigan in Detroit, where a doctor evaluated his X-rays, his physical abilities and his mental health to determine if he qualified for the surgery.

“We give people the pros and the cons,” said Cheryl, a spokeswoman for the institute. However, “we don’t endorse it,” Cheryl also stated.

Since Steve was under 40 and it had been less than 6 years after the accident Steve was a candidate for the surgery. Also helping was the fact that the length of his injury was only 1 centimeter.

“As soon as he found out that he could go, we started raising the money,” Steve’s boss Marion said. “Anybody who knew him donated things or money because we all love him.”

He credits his parents, John and Ruth, and his brother Mark for taking care of his nursing needs since the accident. He’s also appreciative to his employer and his co-workers. Steve can park his minivan in a handicap-accessible space that was created for him. A fund-raising effort — Friends of Steve — spearheaded by his boss Marion, helped raise $39,000 for the operation. (His family covered the remaining costs). The Friends of Steve effort will carry on over the next year to help raise money for therapy costs and equipment.

Steve will return to the United States a week from today, where he’ll begin rehabilitation. To him, the trip and the surgery are worth the risks.

“If I didn’t do this,” he says, “I’d regret it.”

Stem Cell Treatment Study for Peripheral Artery Disease Underway

Peripheral artery disease affects tens of thousands of people. Also referred to as PAD, the disease affects blood circulation, generally in the legs resulting in sores, ulcers, and in some cases amputations. For those that are suffering, a unique clinical trial being conducted at the University of Indiana involving stem cell injections as a treatment may be the answer.

Half of the projected 10 million afflicted Americans who are diagnosed have no symptoms, but others report varying levels of pain as well as other symptoms which include numbness and sores on the legs and feet. The disease is caused by atherosclerosis which can lead to heart attack by clogging and hardening the arteries.

Dr. Michael, who is an assistant professor of surgery and a researcher at the Indiana Center for Vascular Biology and Medicine at the medical school, is leading the stem cell trial. Weight loss, eliminating smoking, and maintaining a proper diet are initial suggestions for management of the disease. Cholesterol-lowering drugs may be prescribed if appropriate. An angioplasty procedure that expands the blood vessels or an artery bypass graft may be treatment alternatives if the disease continues to progress.

However, Dr. Michael says that the surgical measures are not feasible for as many as 12 percent of those individuals afflicted, and that 30,000 to 50,000 people in the U.S. receive amputations due to PAD. The quality of life for a person fighting terminal cancer is comparable to that of someone who is severely affected by PAD.

With the potential to generate the cells that compose the lining of blood vessels, specialized descendants of stem cells called progenitor cells are being used in the IU trial. These “parent” cells can produce new specialized cells in the body when required and fall beneath the class of adult stem cells.

The patient is placed under general anesthesia and bone marrow is extracted from the patient