Stem Cell Treatment Leads to Improvement in New Jersey Man’s Diabetes

Within one month after being treated with adult stem cells in Cologne, Germany, Calvin who is a retired Fire Captain from New Jersey is reporting lower blood glucose levels and decreased insulin doses. Calvin traveled to Germany with peripheral artery disease and erectile dysfunction resulting from his type 2 diabetes.

Using small amounts of his bone marrow, Calvin was treated at the XCell-Center with adult stem cells derived from his own body. Via the femoral artery, a minimally invasive procedure was used to introduce the stem cells to Calvin’s pancreas directly. Stem cells were also introduced into the arteries that supply the penis and into his calves and thighs in order to alleviate the erectile dysfunction and peripheral artery disease that is common amongst complications associated with diabetes.

“Before scuba diving this past Sunday morning, I injected only 32% of my normal insulin dose. During the day, I ate normally – for a diabetic – without injecting any more insulin. That evening, I measured my blood sugar and I was astounded that it was only 126. A month ago, even with my full insulin doses, I never had readings below 170,” said Calvin.

Calvin is not new to the process, over the past two years his current conditions are in fact the third, fourth, and fifth conditions he has received stem cells for. He was featured in Business Week Magazine after a January 2005 stem cell infusion for coronary artery disease. Then, using minimally invasive surgery he was treated again for ischemic cardiomyopathy in September of the same year.

“Actually, what really got my attention this past weekend was that I also felt a regeneration of heart function

Paralyzed Rats Walk Again After Human Adult Stem Cell Treatment

Researchers from the University of California, San Diego (UCSD) School of Medicine are reporting that six weeks after receiving grafts of human spinal stem cells (hSSCs), paralyzed rats regained almost normal ambulatory function. The animals were paralyzed due to loss of blood flow. The study has been published in the June 29, 2007 edition of Neuroscience. UC San Diego professor of anesthesiology Dr. Martin Marsala, M.D. led the study.

“We demonstrated that when damage has occurred due to a loss of blood flow to the spine’s neural cells, by grafting human neural stem cells directly into the spinal cord we can achieve a progressive recovery of motor function,” said Marsala.

“This could some day prove to be an effective treatment for patients suffering from the same kind of ischemia-induced paralysis.”

Marsala hopes to be prepared to carry out human clinical trials by next year. The current focus is on using animal models to establish effectiveness and safety of the human stem cell therapy.

For those individuals who undergo aortic cross-clamping, 20 to 40 percent of patients experience spinal cord ischemia as a consequence of the surgical procedure. It is a serious complication and causes paraplegia. During the procedure to correct a potentially lethal aneurysm, blood flow from the heart must be temporarily blocked with a clamp as the surgeon works on the aorta. Even though the spinal cord remains intact, loss of muscle control or irreparable rigidity and spasticity of the lower limbs can occur due to the lack of blood flow that results in the death of spinal inhibitory neurons which are specialized spinal cord neurons. After only 30 minutes, the neurons become susceptible to death.

“The important difference between spinal cord ischemia and spinal cord trauma, such as might occur in a diving or car accident, is that in the ischemia model, no mechanical damage has occurred to the spinal cord,” said Marsala.

“The spinal cord and brain motor centers are still partially connected, but there has been a selective loss of inhibitory neurons in the spinal cord. Since these cells are necessary for coordinated motor activity, our research aims to replace these lost neurons by grafting new spinal stem cells, which repopulates the pool of degenerated neurons.”

Human spinal stem cells were injected into nine rats 21 days after spinal cord ischemia was induced. There were a total of 16 rats used in the study and the seven non-stem cell rats were injected with a placebo medium containing no stem cells. Every seven days the motor function was recorded and in the rats that received stem cells, a progressive recovery of ambulatory functions was observed.

In all lower extremity joints, three of the nine rats injected with hSSC’s improved their mobility, but most compelling was that another three actually returned to walking after six weeks. According to Marsala, in all nine rats, the majority of transplanted human spinal stem cells survived and became mature neurons. In the spinal area, all the animals had a constant presence of transplanted cells and compared to the control group the hSSC’s rats all achieved significantly better motor scores. Similar results were achieved during a second study which was conducted over three-months.

“Other human stem cell transplants in the spinal cord have focused on repairing the myelin-forming cells,” said co-author Karl Johe, a researcher at Neuralstem, the company that manufactures the hSSCs used in the study. “In this study, we succeeded at reconstructing the neural circuitry, which had not been done before.”

The researchers believe that the therapy may eventually be confirmed to be even more successful in human patients, who would be able to receive physical therapy once treated.

Saying that the goal is to offer a significant gain in functional mobility of the patient’s legs Johe added that, “physical therapy may accelerate integration of the grafted stem cells and enhance their therapeutic benefit.”

Marsala has a history working with human neuronal stem cells. A previous work also using rat models was published in the October 2004 issue of the European Journal of Neurosciences. 40 to 50 percent of the animals tested in that study had significant improvement in motor function. The progress was measured by recording improved muscle tone and the suppression of spastic movements. In the spinal cords of the rats that received transplanted neuronal cells, a post-mortem study showed an increase in the expression of inhibitory neurotransmitters and a robust maturation of neurons.

Spinal drug treatments using implanted pumps or continuous systemic drugs make up the current and somewhat effective standard treatment for debilitating muscle spasticity. These treatments are susceptible to eventual drug tolerance which lessens their efficacy, and are also accompanied by side effects.

“These research findings could offer great hope to people with spinal ischemic injury who suffer from resulting spasticity and rigidity,” said Marsala.

Umbilical Cord Blood Stem Cells and Their Importance

The placenta and umbilical cord contain blood that is jointly referred to as umbilical cord blood. Following the delivery of a baby, the blood is extracted right away. This blood is an extremely rich source of adult stem cells. Stem cells can begin replenishing or repairing old cells in the body by adjusting at anytime. And by having the capability to transform into new brain, blood, heart, and other types of cells; stem cells can bee viewed as the architects of the human body.

Information about birth defect, various diseases, and other ailments, can be discovered by scientists through stem cell research. The underlying secrets responsible for deformities and genetic diseases can be discovered with study. Stem cells have the power to create any cell the body needs by multiplying many times over until the body has repaired itself.

There are a vast number of conditions and diseases that are currently being treated using umbilical cord blood stem cells.

Extensive research is being conducted the benefits of cord blood stem cells in ailments like Brain tumor, Ovarian cancer, Small cell lung cancer, testicular cancer, Rheumatoid Arthritis, spinal injury, diabetes, Parkinson

False Hope Comes with Embryonic Stem Cells

Lobbying for the passage of a bill authorizing federal funding for embryonic stem-cell research, Rekha and others who have been affected by Lou Gehrig’s Disease (ALS), were in Washington D.C. earlier this month. On May 18th, Rekha wrote a column titled, “ALS Activists Fight for Research, Cling To Hope”. The material was infuriating and heartbreaking at the same time; Rekha believes that embryonic stem cells “may hold the key to finding a cure.” However, she was mistaken.

For the treatment of injuries and diseases, only adult stem cell have been proven effective.

Even the American College of Pediatricians (ACP) called for an end to embryonic stem-cell research, “which prolongs needless suffering by delaying the development of more promising adult stem-cell treatments and cures.” On May 14th, this entire medical organization backed up the fact that embryonic stem cells are just not necessary.

Exclusive use of adult stem cells has resulted in the successful treatment of dozens of conditions and diseases over the last decade. The ACP cites these strong pro-adult stem cell results further noting, “catastrophic results…producing the wrong tissue, forming tumors and triggering immune rejection,” when describing the abysmal failure that embryonic stem cell trials have produced. Asserting that it, “steals resources away from the established utility and potential of adult stem-cell research”; the medical group denounced embryonic stem cell research as a tremendous waste of money and resources.

Afflicted patients and their families continue their journey on a path that leads to nowhere because of people like U.S. Senator Tom Harkin who is a sponsor of the embryonic stem cell bill.

Heartless and cruel are only a few of the words being used to describe opponents of embryonic stem-cell research. But offering false promises to millions of desperate people who are suffering from diseases and conditions that could be treated with adult stem cells right now may be even more heartless.

Parkinson’s Disease Seemingly Cured with Indian Stem Cell Therapy

America citizen Andrew traveled to Manipal hospital in Bangalore for stem cell treatment and recovered from Parkinson’s disease after U.S. doctors were of no help.

The trip to India was a last resort for Andrew, who had been suffering with Parkinson’s for more than 15 years. Treatment at U.S. hospitals had provided zero results so he decided to try stem cells as a last go. His personal comfort and feeling of well-being have increased, but more noticeable to others is the fact that his tremors have reduced significantly and he can now walk without support one year following the treatment. The last few months have brought the elimination of his Parkinson’s medication as well. For those suffering with Parkinson’s disease, Andrew’s recovery will give them plenty of hope.

Said R Basil, M.D. and CEO, Manipal Health System, “The successful clinical outcomes from our stem cell research program have given us the confidence to share this new hope with the public at large so that a greater number of people can participate in the clinical research for getting relief from major diseases and disabilities.”

To determine the full ability of stem cells in treating disabilities and diseases that no current treatments offer much hope for is the goal for the team of accomplished stem cell research clinicians, led by Chief Scientific Officer of Stempeutics Research Pvt Ltd, Dr. Satish Totey. Using human adult stem cells, the development of stem cell based therapies is the goal of the Stem Cell Research Center.

While delivering his presentation about the remarkable recovery of Andrew, Dr. Venkataramana said, “Stem cell research seems to be promising in regenerating hope to cure PD. This will motivate innumerable patients across the world to explore this new modality. However, we need to observe the long-term clinical effects in large number of patients to decide its role in the treatment of the degenerative diseases.”

According to Dr. Nagendra Swamy, Group Director- Medical Services, Manipal Health Systems, “Stem cell research has attracted wide attention from all medical fields in the world. The research involving human pluripotent stem cells promises new treatment and possible hope for many devastating diseases. This research Centre will promote cutting edge research which can be translated into clinical applications. This would support the in treating the diseases affecting heart, brain, liver, kidney, bone, spinal cord and vascular. This promises to be the future of medicine in coming years and Manipal is proud to be a leader in this science.”

People over the age of 50 make up the majority of those suffering from Parkinson’s. Current treatments cannot halt the progression of the disease, but can only alleviate a few of the symptoms.

U.S. Researchers Still Question Stem Cell Therapy, But Can’t Deny Effectiveness

Some U.S. researchers warn that much remains unknown, still, local patients are going overseas to put their hopes and spend their money on stem cell treatment.

Currently, adult stem cells are being used in numerous clinical trials worldwide to establish their effectiveness in treating patients with cardiovascular diseases. 67 trials are acknowledged by the National Heart, Lung, and Blood Institute for investigating how to regenerate damaged heart tissue. But a biotechnology firm is saying that they have already accomplished just that.

The company TheraVitae operates in Thailand and Israel, with pre and post treatment care performed by Dr. Zannos Grekos, a Bonita Springs cardiologist.

Stem cell researchers said that before putting their confidence in procedures like the ones Southwest Floridians are seeking, they want to discern much more about stem cells. The cardiovascular experts contacted for this report did not want to discuss TheraVitae directly.

“There are little niches here and there doing various types of treatments without much science,” said Dr. Carl Pepine at the University of Florida. UF is part of the Cardiovascular Cell Therapy Research, a five-member consortium conducting research with the backing of the National Heart, Lung and Blood Institute.

Treating those diagnosed with heart failure and those who have had heart attacks using stem cells is the focus of Pepine’s research.

“Nobody knows what the proper dose is,” Pepine said. “How many cells should you give?”

How soon a patient should receive cells following a heart attack will also be investigated by Pepine’s study.

Sonia Skarlatos says that researchers are trying to determine which variety of stem cell is really responsible for tissue regeneration. Sonia is the acting director for the division of cardiovascular diseases at the National Heart, Lung and Blood Institute.

“We are still not sure what is the right cell, what is the right delivery and what is the right dose,” Skarlatos said.

Skarlatos says that it is tough to draw conclusions from the small-scale studies that have been conducted all over the world. Various doses of cells and different types have been used on patients who all have varying degrees of heart functionality.

“It makes it very hard to compare all the trials,” Skarlatos said.

But the one thing that Skarlatos does agree with is that stem cell treatment is safe. And that is good news for patients wanting to at least give the cells a shot at healing their ailments.

Part of the explanation that patients see progress could be due to the development of new vessels that stem cells encourage says Dr. Johnny Huard, the director of stem cell research at the Children’s Hospital of Pittsburgh. Huard said that too much vascular growth could also be a problem.

Huard is also curious to find out if other parts of the body could also be affected by stem cells injected into the heart.

“One thing is very important: You may inject cells in the heart, but are they migrating?” he said.

50-year-old Neim flew to Bangkok last November for stem cell treatment to heal his deteriorating heart.

He has gotten used to people and their questions about the treatment.

“(My cardiologist) just kept hoping for improvement. Finally, he broke the news. He gave me my time

National Pediatric Doctors Group Wants Exclusive Support of Adult Stem Cell Research

Rather than have federal and state governments throw money away by funding studies that focus on embryonic stem cells, a national group of pediatric doctors want the money redirected towards adult stem cells research. The significant success adult stem cell research has shown over embryonic research provides data to back their cause.

Exclusive support of adult stem cell research is what the American College of Pediatricians is recommending to public officials.

“Not only does embryonic research require taking the life of human embryos, it also prolongs needless suffering by delaying the development of more promising adult stem cell treatments and cures,” said Michelle Cretella, MD, a fellow of the American College of Pediatricians.

Dr. Cretella cites the use of adult stem cells derived from umbilical cord blood, placenta, amniotic fluid, various organs, adult blood, and fat, as proof. These non-embryonic sources have thus far yielded impressive results.

Cretella explained that certain forms of cancer therapy make routine use of adult stem cells today.

But successful treatments have not been limited to cancer. Parkinson’s disease, diabetes, spinal cord injuries, heart failure, and dozens of other health problems have been treated with exceptional results in human trials over the last decade.

“This has not been the case with any embryonic stem cell trial,” the pediatricians’ group’s spokeswoman said. “Instead, there have been catastrophic results with these cells producing the wrong tissue, forming tumors and triggering immune rejection.”

“Every dollar spent on the failed and unnecessary process of embryonic stem cell research steals resources away from the established utility and potential of adult stem cell research,” Cretella concluded. “This is fiscally irresponsible and medically unconscionable.”

Government entities are not hte only ones who have put an emphasis on embryonic stem cell research spending.

Patients were shown to develop insulin independence when Brazilian scientists treated those suffering from Type 1 diabetes with adult stem cells this past April.

But the study received no funding at all from a leading U.S. diabetes group. This same group helped to almost force taxpayers to fund embryonic stem cell research by funding lobbying efforts to push Congress to approve the bill.

Scientists found that 14 of the 15 patients involved with the diabetes study became insulin free. The findings were published in the most recent issue of the Journal of the American Medical Association.

Working with the scientists was Northwestern University’s Feinberg School of Medicine in Chicago doctor, Richard Burt.

“It’s the first time in the history of Type 1 diabetes where people have gone with no treatment whatsoever … no medications at all, with normal blood sugars,” he says of the groundbreaking study.

For the millions of Americans who suffer from diabetes, the results of the study would be miraculous.

But the Brazilian Ministry of Health and a private corporation had to provide funds to the researchers as the JAMA article reads. American’s should feel dismayed that countless sums of money lobbying Congress to fund embryonic stem cells research have been spent by the Juvenile Diabetes Research Foundation and the American Diabetes Association, and not directed towards the diabetes study conducted in Brazil. The prominent diabetes entities chose to back research that has yet to help even one single patient.

Both organization were asked why they did not help fund the Brazilian diabetes study, but neither organization responded to any e-mails that were sent.

They “were not interested in the approach,” said Burt to the AP when confirming their non-participation.

Girl with Cerebral Palsy will Leaves UK for Stem Cell Treatment

To provide their eight-year-old daughter a revolutionary new treatment, a Bournemouth couple is trying to raise

MS Patient Chooses China Over U.S. Due to Cost

Mike will leave for China two weeks from today. He’s not much of a gambling man, but he decided to take one this time. With the hope that his multiple sclerosis will be brought under control, he will undergo adult stem cell treatment overseas.

Riley’s doctors only gave him negative opinions about the treatment abroad. But Riley was smarter than his doctors. He knew that he could become paralyzed in a few years due to his aggressive form of MS, and that he had run out of options in the United States. He couldn

Stem Cells Lessen Suffering for People with Multiple Sclerosis

Therapeutics Daily

The redistribution of a patient’s own adult bone marrow cells as a method of stem cell treatment may lessen the suffering of their multiple sclerosis symptoms.

Professor Neil Scolding of the Institute of Neurosciences at Bristol University’s Frenchay Hospital is researching the use of adult bone marrow stem cells as a therapy treatment for MS.

This type of cell is already used to treat other common conditions such as cardiac disease. They can replace damaged cells by reforming and regenerating.

The scope of stem cell treatment is expanding everyday says Scolding. The Multiple Sclerosis Ireland organization will be hosting him this weekend at their annual conference.

“In the last three or four years we’ve found that stem cells have a number of properties that make them particularly valuable for [ treating] multiple sclerosis. We used to think of stem cells as an opportunity to replace another cell, but it turns out that there can actually be many more things: we can stimulate a local cell or suppress inflammation in its immediate surroundings, which is very valuable in MS,” he says.

The procedure would involve removing bone marrow from the patient and injecting back into the bloodstream making it rather straightforward. The cells would travel almost instinctively to those areas of the body that need attention says Scolding.

“When the cells are injected, they know where to go and from there we hope they will help the tissue to repair,” he says.

Well documented work with other stem cell therapies gives his current research a boost says Scolding. Proof backing up the scientific grounding of treatments in regards to stem cells used in procedures is cited in papers documenting years of successful bone marrow transplant recipients.

“One of the advantages of using bone marrow stem cells is that people for very different reasons have had bone marrow transplants, and they also got those cells,” he says.

“And that means we’ve got 30-40 years’ worth of clinical experience to prove that they are safe and don’t form tumors. They come from the patient and go back to the patient.”

However, as they continue to draw more controversy, embryonic stem cells are falling further behind in terms of research. Many people consider embryos an unethical source of stem cells because it involves the destruction of human embryos.

In contrast to their adult stem cell counterparts, embryonic stem cells are not as reliable says Scolding.

“Quite apart from the ethical questions, there are also very serious biological reasons why embryonic stem cells at the moment are not safe enough to use in therapy,” he says.

“They can form tumors and there is a question of rejection because you are introducing the stem cell into a different patient.”

Scolding says that the answer to the fight against a wide range of health issues can be found in adult stem cells. Before embryonic stem cells can be used as a treatment of any sort, they will need to prove themselves. The process could take at least 10-15 years, if ever added Scolding.

“People are thinking very seriously about using stem cells to treat Parkinson’s disease and diabetes,” he says.

“With MS, we’re not at the stage where we have a lot of results yet, but it’s the beginning of what we hope will be a long journey.”