New York Woman Feels Good Enough to Dance After Stem Cell Treatment

The life of a New York woman was almost destroyed because of a root canal treatment that became infected. Once an active individual, the infection spread causing Ann to have difficulty breathing as the bacteria multiplied and spread towards her heart. Her heart began to fail when one of her heart valves stopped functioning properly.

Ann was rushed to have immediate valve repair once the doctors found the source of the problem which was initially mistaken for pneumonia. She grew sick of being tired all the time as the months following surgery became a struggle.

A company in Bangkok, Thailand was reporting success using a patient’s own adult stem cells to treat cardiomyopathy, ischemic heart disease, and congestive heart failure. The woman investigated further, intrigued by the possibility of getting her life back. Ann had made up her mind to the extent of 50/50, but the tipping point came when over Thanksgiving, she couldn’t pick up her grandson.

Woman’s Heart Rebuilt with Stem Cells

She was at a wedding last summer when she suffered her fourth heart attack. Carron was hanging Japanese lanterns as part of her job when the 58-year-old event planner and mother of two felt the familiar pain in her chest. The doctor told her that she was on her last string and the next time could be her last. An evaluation showed that she was getting less than 50% efficiency from the right side of her heart. Stents didn’t work so they tried a defibrillator. When those measures proved unsuccessful, a heart transplant list got another name.

“All I could do was cry,” she says. “I just thought, ‘I’m about to die.’ There’s 100,000 people waiting for a heart.”

As autumn approached, her condition worsened.

“I couldn’t walk 20 feet without being on somebody’s arm,” Morrow says. “I couldn’t go to the mall. My legs just wouldn’t carry me. I knew I had really gotten worse.”

Her church rallied and offered support.

“Each time I’ve had one of these heart attacks, the church has surrounded me in prayer,” she says.

Carron’s health records were eventually sent to Texas thanks to her nurse. She had been researching adult stem cell therapy and had watched over Carron since her third heart attack. It was during her research that she learned of a groundbreaking study at the Texas Heart Institute.

“Within a month’s time, I was in Texas,” she says.

But the study would be limited, with only 30 people admitted. There would be 10 placebo patients, and 20 stem cell patients.

“I started praying,” Morrow says. “They called me at a quarter to five.”

More than a decade ago, the research began in Brazil, and now Carron would be involved with it.

The treatment was not approved by the Food and Drug Administration, and for the surgery to take place, she had to sign liability papers.

“My next choice was just to drop dead, so I signed everything,” she says, “and had full confidence in that group.”

Carron when into surgery on October 14th, 2006 – her birthday. From her left hip, 50cc of bone marrow was removed and stem cells were cultivated from the tissue. She was back in surgery only four hours later, and the right side of her heart was injected with 30 million stem cells.

Carron had a great deal of traveling to do after the procedure. She remained in Texas for nine days, but had to return every two weeks until January. All her plane trips were paid for by a local businessman who as a catering client of hers.

“I knew within two months something was going on,” Morrow says. “I could sing a whole song at church.”

By December, she “was plating food as hard as any other chef there.”

In April, “I had a huge wedding in Jackson, Mississippi. We put in 80 hours that week. My sister said, ‘Carron, you know you have the stem cells.'”

It was confirmed the following week in Texas: “This little bitty envelope had ‘stem cell’ in it.”

To measure her progress, she had another CT scan performed on her heart. She went to the University of Alabama for the scan this month, the same place where she was informed of her bleak outlook only a year ago.

“The doctor calls and says, ‘Ma’am, the right side of your heart is normal.'”

She had the scan results faxed to Montgomery because she was sure there had been a mistake.

“I was in la-la land for several days.”

On June 7th, she was on PBS in a featured documentary.

“I told the doctor, ‘I don’t understand why we have this huge political mess going on about stem cells,'” Morrow says. “I’m living proof that adult stem cells work far better than embryonic. And why should embryonic even be in discussion?”

“I’m here to say, ‘I’m living proof. It saved my life.”

“I’m just doing great.”

Her defibrillator is no longer needed, an $85,000 remedy that completely failed. Less than $600 was needed to culture Carron’s stem cells.

“This is going to revolutionize heart disease.”

“This community has been such a strength for me,” she says. “I am just so blessed. I feel so undeserving. I am not a perfect person. I just am overwhelmed with how good God is to me.”

“I have been given an opportunity

Dilated Cardiomyopathy Treated Using New Adult Stem Cell Treatment

The condition of “heart muscle disease” is often referred to as cardiomyopathy. Often leading to heart failure or sudden death, it occurs in both women and men. Cardiomyopathy is also a term describing a series of disorders causing primary heart muscle dysfunction. There is no known cure for this condition, of which the most common form causes 10,000 deaths each year in the United States.

Now adult stem cells may be the treatment answer for this condition. A Bangkok, Thailand, based company claims to have developed a treatment for dilated cardiomyopathy. Patients are typically characterized by low energy, pain, restricted activity, brevity, and cost. But patients can travel to Bangkok to for stem cell treatment and possibly leave the aforementioned symptoms behind.

A Michigan man named Jason is perhaps the clinics biggest success.

By the time Jason was 15, he had a pacemaker. By 21 he was diagnosed as having cardiomyopathy and by 25 he had a defibrillator in place and an ejection fraction of just 8-10 percent. Jason was born with an atrial septal defect. Now 34, Jason calls himself lucky. Adult stem cell therapy freed him from the domination and restrictions of heart failure. He says he feels so much better that if he started training, he thinks he could do a triathlon.

As he was removed from a heart transplant list, his mother searched for help. As he went back and forth to specialists having his medications reviewed, since that is all he was left with. He constantly felt depressed and tired since some of the medications had unpleasant side-effects. Then his mother found the stem cell clinic. After being examined by Dr. Patel from the University of Pittsburgh, he was on his way to Bangkok. Dr. Patel felt that adult stem cells could help Jason.

A small amount of blood was withdrawn from Jason once he arrived in Bangkok. Stem cells were harvested from the blood and injected directly into his heart muscle at the Bangkok Heart Hospital. Jason knew his life was changing only a short month later.

“My heart was beating better, more rhythmically, and I had more energy,” he said. “After six months I was up and flying, feeling 100 percent different. I could mow the lawns, take walks, ride a bike with my kids, lift weights — do whatever I liked,” he said. “I’m always on the go with our fifth child on the way and always busy as a full-time parent.”

Jason is very happy to spend time advising other cardiomyopathy sufferers of the power of positive thinking and he has always enjoyed a huge level of support from his family and friends.

“Always try to be positive,” he counsels. “There is hope. Take care of your diet and help get the word out that adult stem cell therapy is worth getting done. It’s nothing like what you would have thought.”

Jason talks to other patients about his treatment, which is not available in the United States, and explains what it is like to fly to Thailand and receive stem cell injections.

Continuing research is revealing encouraging clinical outcomes for adult stem cell use for the treatment of many different conditions. Soon, more patients will be aware of the option to travel abroad to Thailand as well as other countries for treatment. Those patients will know that skilled doctors in world-class hospitals can perform this procedure which is straightforward and effective; and that they cannot be harmed by a therapy that uses their own adult stem cells.

$2.4 Million Dollars Awarded for MS Research Using Bone Marrow Stem Cells

CBC News

A $2.4-million grant was awarded to two Ottawa researchers for their work in fighting the chronic and often disabling disease of the brain and spinal cord that is multiple sclerosis.

Dr. Harry Atkins and Dr. Mark Freedman will continue a closely watched clinical trial involving an experimental bone marrow stem cell transplant therapy. Their team was awarded the money by The Multiple Sclerosis Society of Canada.

Improvements in the ability to walk and see have been among the most dramatic observations of their MS research along with data on MS symptoms slowing down.

“The idea behind this clinical trial is to replace the diseased immune system with a new one derived from the patient’s own bone marrow stem cells,” said Atkins, a scientist at the Ottawa Health Research Institute, and a bone marrow transplant specialist at the Ottawa Hospital.

“First, we purify and freeze the patient’s stem cells, then we use strong chemotherapy to destroy their existing immune system,” he said. “We then transplant the purified stem cells back into the patient.”

“It takes time, but eventually these stem cells will form a completely new immune system — one that does not attack the brain and spinal cord — we hope.”

Researchers say that applying the procedure to treat autoimmune diseases such as MS is novel, but a similar procedure has been used to treat certain types of blood cancer for more than 25 years.

“We hoped that this therapy would halt or slow the progression of MS, and in the patients examined so far, it seems to have worked,” Freedman said. “In addition, some patients have experienced substantial improvements in their ability to see and walk.”

“This was unexpected, and it suggests the exciting possibility that the therapy may be contributing to some sort of repair or regeneration. With this funding, we can investigate this further.”

The knowledge gained could lead to significant improvements in the treatment of MS and other autoimmune diseases, even though the therapy is highly experimental researchers said.

Making it the most common neurological disease of young adults in Canada, between 55,000 and 75,000 Canadians have multiple sclerosis. People are typically diagnosed with MS between the ages of 15-40.

Stiffness of muscles, extreme fatigue, speech problems, loss of balance, double or blurred vision, bladder and bowel problems, or even partial or complete paralysis can be among the unpredictable and varying symptoms that a person with MS can experience.

$2.4 Million Dollars Awarded for MS Research Using Bone Marrow Stem Cells

A $2.4-million grant was awarded to two Ottawa researchers for their work in fighting the chronic and often disabling disease of the brain and spinal cord that is multiple sclerosis.

Dr. Harry Atkins and Dr. Mark Freedman will continue a closely watched clinical trial involving an experimental bone marrow stem cell transplant therapy. Their team was awarded the money by The Multiple Sclerosis Society of Canada.

Improvements in the ability to walk and see have been among the most dramatic observations of their MS research along with data on MS symptoms slowing down.

“The idea behind this clinical trial is to replace the diseased immune system with a new one derived from the patient

Blood Vessels Created Using Adult Bone Marrow Stem Cells

Using a person’s own bone marrow, doctors were able to grow new blood vessels. However, in order for patients with diseased arteries to benefit from the test-tube grown vessels, a few more years of research will be required said researchers. Still, the accomplishment is yet another large step for adult stem cells and demonstrative of their therapeutic potential.

“Our studies show that bone marrow is an excellent source of stem cells that can be coaxed into creating blood vessels,” Stelios Andreadis, associate professor in the University at Buffalo department of chemical and biological engineering, told United Press International.

Andreadis said that endothelial and smooth muscle cells make up the test tube created blood vessels.

“These stem cells can be used in regenerative medicine for cardiovascular applications,” he said.

Especially for those found in and around the heart, the main reason for creating new blood vessels is for use in arteries said Andreadis. However, the blood vessels created in his laboratory are capable of being used, at the very least as, veins in humans right now.

The new blood vessels should be engineered to withstand internal pressures as high as 1,200 millimeters of mercury in order to have the strength to be used to replace diseased coronary arteries. This is 10 times above the normal limit. Having a top strength of about 200 mmHg, bone marrow stem cell derived blood vessels are not yet strong enough.

“We need to improve the matrix around which the cells grow in order to have strong enough blood vessels for replacing human arteries,” he said. The researchers have already used tissue engineered vessels in animals such as sheep with good results, he said.

Cardiovascular Research recently published Andreadis’ preliminary work. Providing a desirable alternative to the venous grafts now routinely done in patients undergoing coronary bypass operations, the paper demonstrated the potential for eventually growing tissue-engineered vessels out of stem cells harvested from the patients who need them.

A high 10-year failure rate, discomfort and pain at the donor site, and the limited availability of vessels are some of the disadvantages of venous grafts.

Using a tissue-specific promoter for alpha-actin (a protein found in muscles that is responsible for their ability to relax and contract) in conjunction with a fluorescent marker protein, Andreadis reported on a novel method for isolating functional smooth muscle cells from bone marrow.

One of the most important properties of blood vessels is their ability to proliferate and the ability to contract in response to vasoconstrictors. In their expression of several smooth muscle cell proteins, the tissue-engineered vessels performed similarly to native blood vessels.

Critical to the functioning of artificial blood vessels, both elastin and collagen are produced by the vessels. These components also give tissue their elasticity and strength.

The John R. Oishei Foundation of Buffalo and the Integrative Research and Creative Activities Fund in the Office of the Vice President for Research at the University at Buffalo, part of the State University of New York funded Andreadis’ research.

“The work in Buffalo shows the promise that stem cells have in their ability to produce different structures,” said S. Chiu Wong, associate professor of medicine at the Weill Medical College at Cornell University. “This pre-clinical work shows again that stem cells can be a rich source for development. It certainly remains a fruitful area of research.”

Working on producing more coronary blood vessels is another aspect of stem cell research which Wong and his colleagues are working on. In an attempt to generate blood vessel growth, stem cells are injected directly into heart muscle. Wong and his team are part of a multicenter clinical trial involved to this particular study which has been funded by Baxter.

Pope Supports Adult Stem Cell Research

On the condition that the work does not involve human embryos, Pope Benedict XVI reiterated the Roman Catholic Church’s support for stem-cell research.

Adult stem cells exist in tiny numbers within developed organs. This was the topic of discussion at a conference at Rome’s La Sapienza University on research into the treatment of heart disease with so-called adult stem cells. The pontiff directed his comments at delegates attending the conference as he held his traditional weekly general audience at the Vatican.

The use of embryonic stem cells is controversial because harvesting the cells involves the destruction of a human embryo. The cells are created shortly after conception.

The church’s position is “clear,” the German-born pope said. “Scientific research should be rightly encouraged and promoted as long as it doesn’t hurt human beings whose dignity is inviolable from the very first stages of existence,” he said.

Based on a conviction that an embryo is a human being from conception and therefore its life cannot be interrupted, the church’s objections to embryonic stem-cell research are the same as its arguments against abortion.

Benedict’s predecessor, Pope John Paul II, outlined the Vatican’s position in a 1995 encyclical, “The Gospel of Life,” saying, “Human embryos obtained in vitro are human beings and are subjects with rights; their dignity and right to life must be respected from the first moment of their existence. It is immoral to produce human embryos destined to be exploited as disposable `biological material.”

The Umbilical Cord Blood Advantage

When cord blood cells are transplanted to patients, a number of ailments have begun reversing their effects as records have proven. Research has shown that diverse treatment strategies for over 70 diseases can be derived from umbilical cord blood stem cells. Where re-growth of cells is necessary for treatment and bone marrow transplants are the current mode of treatment, research is being conducted to see the potential of cord blood stem cells in this category as well.

Researchers claim that bone marrow and its hemapoietic characteristics can be found in umbilical cord blood stem cells as well. The cells that make up the various organs throughout our body can be developed from these particular stem cells. To treat disorders that surface in the various organs, cord blood stem cells are typically chosen due to their versatility. But those suffering from blood disorders make up the majority of the recipients of cord blood according to records.

Platelets, white blood cells, and red blood cells can all be created by umbilical cord blood stem cells. Fanconi, Anemia, adult and child leukemia, lymphoma ,and most other malignant blood disorders are treated with cord blood stem cells for this very reason. Parkinson’s disease, immune system disorders, heart muscle disorders, cardiac diseases like heart attacks, severe spinal cord injuries, and some sight disorders, are among the life threatening diseases that have been successfully treated using umbilical cord blood stem cells.

Cord blood stem cell transplants are most commonly administered to those patients who decide to forgo the painful procedures involved with a bone marrow transplant. Children and young adults have been the primary recipients of cord blood cell transplants. One of the reasons for this is that as a recipient becomes larger, the demands of cell quantity become greater. Most often, the quantity required for adult treatment cannot be found.

Since they are the most primitive cells of the body, they are often referred to as “naive” cells. Thus, where tissue re-growth is needed , they exhibit the adaptability to form the cells of any respective organ. For this reason, the recipient’s immune response is less likely to reject the cells.

Fewer matches of cells can be found for ethnic and racial minorities. Individuals that fall into this category are encouraged to save their children’s umbilical cord blood so that it can be used by their family at a later date if needed. Finding genetically matched cord blood cells is difficult for a few other individuals as well. Others who should seriously consider cord blood stem cell banking are parents of newborn adopted children and those born though in vitro fertilization.

Preserving a baby’s cord blood stem cells makes perfect sense. Offering umbilical cord blood storage, cryogenic facilities or “cord blood banks” are accessible in nearly ever corner of the world today. Since the cells are useful in the treatment of many deadly diseases, they could potentially save a child’s life, or one of his or her siblings, or even another family member. Since it is relatively difficult to find a match for some, those individuals should strongly consider banking as well.

Treatment of Heart Disease Revolutionized by Stem Cells

A leading cardiologist is saying that the treatment of heart disease has been revolutionized by the concept of “growing” heart muscle and vascular tissue and manipulating the myocardial cellular environment by using stem cell therapy.

City-based Harvey Super Specialties Hospital Chairman M P Naresh Kumar told reporters that adult stem cells harvested from peripheral blood or bone marrow are capable of replicating, differentiating and promoting heart muscle (myocardial) repair.

He said that recently, adult stem cells have proven themselves to have great therapeutic benefit and clinical relevance for the treatment of heart disease, even though there is still experimental work that must be completed.

Severe heart disease cases that have been treated successfully with adult blood stem cell infusions were cited as examples of recent stem cell success by Kumar. Once such example involved a 53-year-old woman. After all other treatments proved to yield no benefit, the woman, who also suffered from diabetes and high blood pressure was treated using adult stem cells.

A heart transplant was out of the question for her and beyond her means. Her ejection fraction had dropped to 35 percent and she had severe heart failure. Diagnosed with dilated cardiomyopathy, she underwent stem cell therapy as last resort.

Upon discharge following cell therapy, her ejection fraction had already increased to 49 percent. She was infused using a catheter technique via a coronary route.

The accessibility, safety, feasibility, and cost effectiveness, of stem cell therapy was pointed out by Kumar.

He remarked that the treatment cost a relatively small sum of Rs 25,000 (about $610 dollars), where if the treatment had been performed in the United States it would have cost about Rs 40 lakh.

Stem Cells Tested in UK Heart Patients

In order to repair the damage caused by heart attacks, British scientists will be trying a new method to treat the condition. Their hope is to regenerate tissue by using the patient’s own bone marrow. Stem cells taken from the marrow will be injected into the damaged hearts.

60 people who have recently suffered severe heart attacks will be involved in the trial which will be lead by Raimondo Ascione of the University of Bristol. The damaged tissue could potentially be repaired by stem cells that will be injected by Dr. Ascione during coronary bypass surgery. The cells have the potential to differentiate into the types of heart cells needed to fix that patient’s hearts.

About 230,000 people suffer a heart attack each year, making heart disease the biggest killer in the UK. Nearly one-third of those heart attack victims die. Because arteries get clogged with fatty deposits, blood supply is restricted, and this eventually leads to a heart attack. The hearts ability to pump blood is reduced when cells in the oxygen-deprived area die causing scarring.

“One in three people will die within two or three years and the remaining people will have a very poor quality of life,” said Dr Ascione. “Your exercise tolerance will be very poor, you will not to be able to enjoy your life. If this [experiment] works you will minimize this … the point of this trial is to do the bypass and try to repair the scar, to make it a viable muscle again.”

A type of stem cell that only forms about 1% of the bone marrow will be used for the experiment.

“This approach ensures no risk of rejection or infection,” said Dr. Ascione.

Scientists will conduct MRI scans of the patient’s hearts prior to the operation and six months afterwards.

“We expect that part we injected to be repaired and it will pump and contract properly,” he said.

Funding the trial with a