Multiple Sclerosis Patient Improves With Autologous Adult Stem Cell Transplant

Leah Telder of Surrey, British Columbia, had enjoyed ballet dancing until struck with multiple sclerosis in her teens. The demyelinating, auto-immune disorder eventually robbed her of her vision and confined her to a wheelchair. Now 24 years old, Leah is the youngest of seventeen MS patients who have been treated in Canada with their own (autologous) adult stem cells.

Conducted in October of 2007 in Ottawa, the procedure was led by the neurologist Dr. Mark Freedman and the bone marrow transplant specialist Dr. Harold Atkins. In this procedure, stem cells are harvested from the peripheral blood of each patient and are then expanded in a laboratory and readministered after the patient has received a heavy dose of chemotherapy, which is administered with the specific intent of destroying the immune system. Although 16 of the 17 patients are improving as a result of the stem cells, one patient in the study died as a result of the chemotherapy. In fact, at these high doses, each patient has a 5% (or a one in 20) chance of dying from the chemotherapy. Whether or not the chemotherapy even needs to be administered at all is increasingly a topic of debate, and there is strong scientific evidence to support the claim that chemotherapy is unnecessary in this type of stem cell treatment.

Meanwhile, as a result of being treated with this particular chemotherapy procedure, and as a result of being successfully rescued by her own adult stem cells immediately following the chemotherapy procedure, Leah is once again able to walk by herself, and most of her blurred vision has been restored to normal.

Members of Congress are Briefed on the Successes of Adult Stem Cell Therapy

In a bipartisan briefing in Washington, D.C., members of Congress were updated both on the increasing number of successful cases of adult stem cell therapy, and on the increasing number of failures of embryonic stem cells, which have never advanced beyond the laboratory stage.

House Representatives Randy Forbes, a Republican from Virgina, and Daniel Lipinski, a Democrat from Illinois, co-hosted the event in conjunction with the Family Research Council (FRC). Among the researchers testifying before the Congressmen was Dr. Richard Burt of the Feinberg School of Medicine at Northwestern University, whose publication in the Journal of the American Medical Association in February of 2008 garnered widespread attention for its analysis of hundreds of adult stem cell studies that had been conducted between 1997 and 2007, and from which Dr. Burt gathered together an entire decade’s worth of quantitative proof that adult stem cells derived from blood and bone marrow have already been safely and effectively used to treat a number of cardiac and autoimmune disorders.

Congressmen Forbes and Lipinski are promoting the “Patients First Act”, which would legislate and prioritize the funding of stem cell research by stem cell type. According to a representative of the FRC, “Embryonic stem cells have yet to treat a single human patient and this is unlikely to change in the future. Adult stem cells are already providing therapeutic benefit to human patients for 73 diseases and condition.” Also appearing before the Congressmen were several patients who have been successfully treated with adult stem cell therapy, which included Barry Goudy who had been treated for multiple sclerosis, Amy Daniels who had been treated for systemic sclerosis, and Jill Rosen who had been treated for lupus. Each of these individuals spoke about their personal experiences with adult stem cell therapy.

Stem Cell Therapy Could Eliminate the Need for Surgical Joint Replacement

At the annual meeting of the American Academy of Orthopedic Surgeons held in San Francisco this week, researchers and physicians alike have agreed that regenerative medicine will be their most powerful tool throughout the future. Rather than surgically replacing joints, as has been the standard medical approach in the past, therapies of the future will focus on the use of stem cells and gene therapy in the new scientific field of tissue re-engineering.

Dr. Thomas Einhorn, chairman of the Department of Orthopedic Surgery and professor of orthopedic surgery, biochemistry and biomedical engineering at Boston University, performed his first hip “replacement” last year with a new technique that utilizes the patient’s own stem cells. As he stated, “It’s the future of our specialty.”

A handfull of companies, such as Stryker and Medtronic, already sell bone morphogenic proteins (BMPs) which are comprised of certain cytokines and growth factors that induce the formation of bone and cartilage. According to Dr. Scott Rodeo, who is co-chief of Sports Medicine and Shoulder Service at the Hospital for Special Surgery in New York and an associate team physician for the Super Bowl champion team, the New York Giants, BMPs in combination with stem cells have already been used in the successful repair of torn rotator cuffs in animal models, thereby offering a promising new type of therapy, which does not involve surgery, for one of the most common shoulder injuries to occur in sports and which normally has only been treatable in the past with surgery.

Previously, the tools of an orthopedic surgeon have typically resembled those of a car mechanic. The heavy metal and even the newer synthetic and composite materials from which artificial hip and knee joints are still fashioned may soon be replaced by BMPs in combination with adult stem cells that are easily and safely derivable from such sources as bone marrow, fat, and umbilical cord blood.

Athletes with sports injuries, and non-athletes with more ordinary conditions such as osteoarthritis and other degenerative diseases of the bones and joints, are expected to benefit greatly by these new techniques in which adult stem cell therapy is already making surgical joint replacement obsolete.

Mesenchymal Stem Cells Applied to Wound Healing

Mesenchymal stem cells (MSCs) are of great therapeutic interest because they are already known to be not only regenerative but also immune privileged and immune modulatory, unlike most stem cells. Such characteristics eliminate any need for matching MSCs immunologically to the recipient, and because of these "immune privileged" properties, the biotech company Osiris Therapeutics holds a number of patents on MSCs for a variety of allogeneic uses of MSCs such as the intravenous delivery of these stem cells in the treatment of patients with heart failure. Now the extraordinary properties of MSCs have been applied to yet another medical application, namely, to expediting the process of wound healing.

Dr. Yoshikawa and colleagues at the Nara Medical University in Japan have successfully mimicked an artificial dermis layer by culturing bone marrow-derived MSCs on a collagen sponge from which the layer of dermal cells was then implanted subcutaneously into an immune-compromised mouse and explanted after ten days, at which time histological examination revealed the differentiation of the MSCs into dermal tissue in vivo.

The procedure was then applied to 20 human patients who were suffering from pathological skin conditions that were refractory to conventional medical therapies, and for whom the same type of autologous "grafts" were applied to the wound areas after having been created from each patient’s own bone marrow-derived MSCs and the collagen matrix. From this procedure, 18 of the 20 patients were found to have significantly improved.

The procedure offers a promising new therapy for even some of the most severe types of wounds.

Stem Cells Expedite the Healing of Severe Bone Fractures

A team of scientists at the University of Edinburgh in Scotland have developed a “bioactive scaffolding” comprised of materials designed to interact with adult stem cells in such a way that even the most serious types of skeletal injuries may now be able to heal completely. Some types of injuries to bone and cartilage are too traumatic to heal without medical intervention, although the conventional types of orthopedic surgery have not always been successful in repairing such injuries. Now Dr. Brendon Noble and his colleagues at the MRC (Medical Research Council) Centre for Regenerative Medicine in Edinburgh have developed a composite “scaffold” which consists of a rigid mesh structure that has been impregnated with chemicals that facilitate the natural action of stem cells derived from bone marrow. Such a device would be useful not only for treating people who have suffered acute injury, but also for treating chronic conditions such as osteoarthritis and cancer of the bone. People of all ages who may suffer skeletomuscular trauma, especially the elderly, would benefit greatly from such a therapy.

Dr. Noble and his colleagues are working in collaboration with the Scottish National Blood Transfusion Service in the harvesting and culturing of blood-derived stem cells that are known to differentiate into bone, and which are incorporated into this new therapy.

Adult Stem Cells Show Positive Results in the Treatment of Autoimmune, Vascular and Cardiac Diseases

Researchers at the Feinberg School of Medicine at Northwestern University in Chicago have conducted a review of the medical literature in which adult stem cells derived from blood and bone marrow were utilized in the treatment of nonmalignant, nonhematologic conditions. In particular, the scientists and doctors reviewed reports that were published between 1997 and 2007 on the use of hematopoietic stem cells (HSCs) in the treatment of autoimmune, cardiac and vascular diseases. From a total of 926 reports, 323 were specifically analyzed for feasibility and toxicity.

The team of researchers, which was led by Dr. Richard Burt, concluded that adult stem cell therapy is effective at treating the diseases and at relieving the symptoms of the diseases, while contraindications and side effects were negligible, at less than 1% in most studies. As the scientists stated in their own words, and as published in their report in JAMA, “Stem cells harvested from blood or marrow, whether administered as purified HSCs or mesenchymal stem cells or as an unmanipulated or unpurified product can, under appropriate conditions in select patients, provide disease-ameliorating effects in some autoimmune diseases and cardiovascular disorders.”

Researchers hope that the conclusions drawn from such a literature review might encourage further progress in the formal recognition by legislators and the medical community of the clinical safety and efficacy of adult stem cells.

Multiple Sclerosis Treated With Adult Stem Cells

After being diagnosed with multiple sclerosis in 1995, Barry Goudy experienced the slow deterioration of his central nervous system with symptoms that included failing vision, a loss of muscular control and an absence of sensory perception in his limbs. Then in 2003 he enrolled in a clinical trial in which his own adult stem cells were used to rebuild his immune system. As he now states, “I have no symptoms of MS. I do no treatment for MS, I do no shots.”

Dr. Richard Burt and colleagues at Northwestern University Feinberg School of Medicine conducted the clinical trial on 2,500 patients who underwent the stem cell transplants. The results have indicated not only that many patients with autoimmune diseases are now in remission, but also many patients who had suffered heart attacks were found to have improved significantly after receiving the adult stem cell therapy.

As Dr. Burt says, “It’s a whole new approach to these diseases.” In an interview conducted this year, Mr. Goudy adds, “I’ve had 5 years of a good life. Five years. If I didn’t do the transplant I would probably be in a wheelchair today.” Among other activities, Mr. Goudy’s active lifestyle now includes playing and coaching hockey. Similar clinical trials are currently underway in the U.S. for the use of adult stem cells in the treatment of numerous other diseases which typically have been unresponsive to conventional medical therapies.

Investment Firm Selects an Adult Stem Cell Company for its Sound Business Model

The New York based investor and public relations firm known as “Consulting for Strategic Growth 1” (CFSG1) has selected the adult stem cell company NeoStem, Inc., as a sound business model with positive growth and strong financial results.

According to CFSG1, NeoStem’s performance was so successful in 2007 that the company was selected as one of only 3 “stock picks” by the firm for the entire year. NeoStem deals exclusively with adult stem cells, thereby avoiding entirely not only the ethical and political quagmires that are entangled in the topic of embryonic stem cells, but also the countless scientific problems that are caused by embryonic stem cells as well. To date, embryonic stem cells have never actually been used in the treatment of any disease or injury in human patients, and for good reason, since embryonic stem cells have proven to be highly problematic in the laboratory. Ethical and political controversies aside, embryonic stem cells have never advanced beyond the laboratory stage purely for scientific reasons. Consequently, financial experts are now discovering what scientists have known all along: namely, that adult stem cells not only make sound scientific sense, but they also make sound business sense as well.

NeoStem manages a nationwide network of adult stem cell collection centers throughout the U.S., and is one of a handful of companies that are pioneering the collection, processing and long-term storage of adult stem cells for future autologous (in which the donor and recipient are the same person) medical use. As such, not only do companies such as NeoStem eliminate all concerns regarding embryonic stem cells, but problems associated with matching a compatible donor to the recipient are also avoided. Additionally, NeoStem has developed proprietary technology in the collection and isolation of specific types of adult stem cells from the peripheral blood of adults through apheresis, a procedure which is safe, painless, minimally invasive and highly preferable to “bone marrow aspiration”, the process by which stem cells have typically been collected from bone marrow in the past and which is usually performed under general anesthesia due to the amount of pain that is involved.

A number of recent breakthroughs have been reported with adult stem cells in the treatment of various diseases including systemic lupus, multiple sclerosis, scleroderma, peripheral vascular disease, heart disease, and a variety of osteopathic conditions, all of which are included in NeoStem’s research. By contrast, embryonic stem cells have never even been attempted for use in the treatment of any disease or injury in human patients, which is why there is currently no successful business model that exists for the actual treatment of human patients with embryonic stem cells. Also for this reason, the National Institutes of Health (NIH) are currently conducting more than 750 clinical trials with adult stem cells in the treatment of human patients, and zero clinical trials in which human patients are treated with embryonic stem cells.

As reported by CFSG1, NeoStem’s “business model is non-capital intensive, does not depend on risky biopharmaceutical R&D, and is a service model that is completely scalable and can be implemented immediately. All fees flow directly to NeoStem and do not require third-party payment.” Additionally, NeoStem “grew substantially in 2007, meeting all of its milestones for the year.” NeoStem (symbol NBS) is listed on Amex.

As the clinical wisdom and logic of adult stem cells begins to gain popularity over the clinical folly and futility of embryonic stem cells, more and more companies such as NeoStem, which deal exclusively with adult stem cells, are expected to become increasingly financially successful as they fill a widespread, international need for the safe and effective treatment of numerous diseases and injuries, including congenital and age-related conditions, many of which have already been found to be treatable with adult stem cells. One of the world’s premier, most highly respected medical research firms, Frost & Sullivan, has estimated that within two years, by 2010, the global market for adult stem cell therapy will be $20 billion per year. Clearly, excellent investment opportunities are to be found today in those companies which are built upon the sound science of adult stem cell therapies.

Australian Spinal Cord Research Could Bring New Hope

With the first Australian trial of a new adult stem cell treatment, the hope of improved movement for those with spinal cord injuries has been given a new boost.

In order to coordinate national and international research and apply it to patients, the new dedicated spinal cord laboratory at Melbourne’s St. Vincent’s Hospital. The facility is the first of it’s kind in Australia and will be the location where the trial is conducted.

With no cure in sight and the cost of care at an estimated $1.2 billion, Australia sees a new spinal cord injury every single day.

“This is a major unmet medical need,” said Dr. George Owen, head of Step Ahead Australia, (formerly the Spinal Cord Society of Australia).

After diving into a shallow pool 13 years ago, Dr. Owen’s son Sam became a quadriplegic. Sam is now 26 years old.

New leads into the treatment and possible cure for spinal cord injury may be developed during the trial where scientists will work with a spinal cord

Heart Failure Recovery Boosted by Stem Cells

The administration of adult bone marrow stem cells (BMC) and mesenchymal stems cells (MSC) can aid in the recovery of myocardial infarction (MI) – commonly known as heart attack – and consequently increase survival rates according to a study in the Clinical and Experimental Pharmacology and Physiology published by Wiley-Blackwell.

The study is designed to evaluate the impact of systemic delivery of BMC and MSC on spontaneously hypertensive rats induced with MI.

Dr. Nardi, the lead author of the study called,