Roberta F. Shapiro DO, FAAPM&R: “A New York Doctor’s Path to Panama” – A Stem Cell Therapy Video Lecture

Special Guest Speaker, Roberta F. Shapiro DO, FAAPM&R speaks about: “A New York Doctor’s Path to Panama” at the Stem Cell Institute’s Stem Cell Therapy Public Seminar in New York City on May 17, 2014.

Dr. Shapiro discusses how she discovered the Stem Cell Institute and why she started referring her patients to Panama for stem cell therapy.

Dr. Shapiro operates a private practice for physical medicine and rehabilitation in New York City. Her primary professional activities include outpatient practice focused on comprehensive treatment of acute and chronic musculoskeletal and myofascial pain syndromes using manipulation techniques, trigger point injections, tendon injections, bursae injections, nerve and motor point blocks. Secondary work at her practice focuses on the management of pediatric onset disability.

She is the founder and president of the Dayniah Fund, a non-profit charitable foundation formed to support persons with progressive debilitating diseases who are faced with catastrophic events such as surgery or illness. The Dayniah Fund educates the public about the challenges of people with disabilities and supports research on reducing the pain and suffering caused by disabling diseases and conditions.

Dr. Shapiro serves as assistant clinical professor in the Department of Rehabilitation and Regenerative Medicine at Columbia University Medical Center.

Stem cell therapy for COPD

Email from a COPD patient on Jan 8 to Dr. Paz. We have removed this patient’s name since she has not yet informed her doctors in the US about her treatments in Panama. She received multiple intravenous injections of human umbilical cord-derived mesenchymal stem cells over the course of several days.

From: REDACTED
Subject: Re: Surveys
Date: January 8, 2014 at 7:48:49 AM EST
To: Jorge Paz Rodriguez

Dr. Paz,

I definitely feel there is an improvement from the 1st to the 2nd treatment. I feel much stronger and feel that I am able to function with a better quality of life. Prior to my 1st and 2nd treatments it was hard for me to keep up with the housekeeping, cooking, laundry and going out to the store for groceries was very hard for me to do. I have more energy to complete the task at hand now. I am able to walk longer distances without having to sit and rest and not getting as winded walking. Going up and down stairs is easier for me to do. I do feel I am making improvements with each treatment.

I have health insurance again and the Dr. here was wanting to do a physical with a chest X-ray to see the change in my COPD since my last X-ray a couple of years ago. I thought I could send you the X-ray on CD so you could compare the X-ray to what I originally sent you. I have not shared with the Dr.’s or anyone here about my treatments in Panama.

Please let me know about the Survey and if you think I should do the X-Ray and send it to you.

Thank you,

REDACTED

Sent from my iPad

The Science of Mesenchymal Stem Cells and Regenerative Medicine – Arnold Caplan PhD (VIDEO Part 2)

In Part 2, Prof. Caplan discusses the two types of regenerative medicine: tissue engineering and in vivo tissue regeneration, hematapoietic and mesenchymal stem cells. All mesenchymal stem cells are pericytes and have immuno-modulatory and trophic properties

Prof. Caplan was speaking in Panama City, Panama at “La Medicina Del Futuro En El Presente”, an event organized by the honarable Ruben Berrocal MD, Minister of Science, Technology and Innovation SENACYT (National Secretariat of Science, Technology and Innovation) and Prof. K. S. Jagannatha Rao, Ph.D., FNASc, FABAP, FASB, FLS (Reino Unido) Director INDICASAT-AIP (Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia — Institute for Scientific Research and High Technology Services).

Stem Cell Therapy for Heart Disease – Jim Parker Attorney at Law and former Texas State Legislature Member

Stem Cell Therapy Heart Patient Jim ParkerJim Parker, Attorney at Law is a former Texas State Legislature member who was treated with umbilical-cord derived stem cells for heart disease at the Stem Cell Institute in Panama in March 2011.

Jim was kind enough to answer some questions about his condition before and after treatment. He also discusses his trip to Panama, the clinic and its staff.

What is your diagnosis and when were you diagnosed?

Exactly what my diagnosis was I cannot say in medical terms. Factually speaking, I had five (5) by-passes in 1995 (or thereabouts) and then had nine (9) stents added over the next 13 or 14 years. I began to experience severe angina in January and February of 2011 and was hospitalized in February with a series of heart attacks. I had consulted my cardiologist in Abilene and had also gone to a cardiologist in Dallas who was supposed to be really good. They both told me that there was simply nothing else I could do. When I was released from the local hospital in early March of 2011, my family doctor gave me a bottle of morphine and a bottle of nitroglycerine and basically told me to make it as well as I could for as long as I could.

Panama did not exactly change my life. It literally gave my life back to me.

We had heard about the Panama operation (Stem Cell Institute) from local people who had gone for various reasons. Every one of them seemed well-pleased with the results they were able to get. After release from the local hospital in early March of 2011, I sent my medical records to Panama and arranged an appointment in mid-March. I traveled to Panama in a wheel chair because I was not able to walk in the airport.
Upon arrival in Panama the first day was spent drawing my blood for blood tests. The next 7 days the (umbilical cord-derived) stem cells were infused back into my body.

I found the staff to be very helpful and apparently knowledgeable. Our needs outside the clinic were well taken care of and we were very satisfied with our experience.

I steadily improved after Panama to the point where I have now resumed a normal life (at as normal as a 68 year-old guy can expect) and I am back at work. I have not had to use a nitroglycerine pill in over a year and, so far as I can tell, I have no immediate heart problems and but for the damage suffered from my earlier episodes, my heart would be in good shape. My longtime cardiologist will still see me but he believes Panama was some sort of voodoo and I have just been lucky. I continue to take a mild blood pressure medication and I do still take blood thinner. However, about 6 months after Panama my blood pressure got so low they had to cut down the strength of the medication.

What symptoms did you have before you cam for treatment?

Prior to Panama I had a series of heart attacks over a number of years and was eating nitroglycerine tablets like M&Ms.

Which treatments did you try in the U.S. first, and when did you know that you needed to find help outside of the country?

I tried every treatment available in the US of A. Had every test know to man. I mean 5 by-passes and 9 stents many not be a record but it has to be well beyond average.

Why did you choose The Stem Cell Institute in Panama for stem cell treatment?

I chose the Stem Cell Institute in Panama because several local folks had gone there and they were pleased with the results. And, I really had no place to go but the cemetery.

How were the doctors at the clinic? How were the facilities?

The only doctor I recall seeing was Dr. Paz. The facilities were at least on par with what you would find in the US and the staff was more solicitous and helpful than you would find in the US.

How are your symptoms now? How have they improved?

I have no symptoms now. (Knock on wood). I have some breathing issues but I am told that is COPD and it is not really all that bad. I could live another 100 years feeling as good as I do now.

Have you reduced or eliminated any of the medications you were taking before stem cell therapy?

I have cut way back on medication I was using prior to Panama and feel I could probably cut back some more; however, I have to give the local MD’s something to work on. And, by the way, I go to the doctor as little as possible now. Maybe twice a year at most.

How soon did you start seeing/noticing a difference? How was your overall experience?

I began to notice a difference (maybe it was just anticipation) about 6 to 8 weeks after returning from Panama. It has gotten better and better since then. Since I can move around, I have lost over 40 pounds and now am at 6 feet tall and 215 pounds, down from over 250 pounds.

How has this changed your life?

Panama did not exactly change my life. It literally gave my life back to me. I have been married to the same woman for over 50 years and we were able to become intimate again. I am out and about every day and pretty much do what I want to do and go where I want to go.

Additional Comments

Many people should know about this option. There are people dying here in the land of the free and the home of the brave each day that are in better shape than I was when I went to Panama.

And, by the way, I am not subject to flights of fancy and accepting things a thinking person might not accept. I hold a doctor of jurisprudence degree and have been a criminal defense attorney all my adult life. I am about as cynical and skeptical as you will find but I am a believer in your process.

Thank you,

Jim Parker

Allogeneic and autogolous stem cell therapy combined with physical rehabilitation: A case report on a chronically injured man with quadriplegia

Allogeneic and autogolous stem cell therapy combined with physical rehabilitation - A case report on a chronically injured man with quadriplegia

Daniel Leonard in Panama

This is a research paper written by Rebecca Johnston, Daniel Leonard’s sister. She recently graduated from a Physical Therapy degree program, and wrote her Capstone paper about Daniel’s stem cell therapy treatment in Panama.

Daniel is presented anonymously in the paper, but Rebecca and Daniel have given their permission for this paper to be shared. Daniel’s ASIA scores (pre and post treatment) are in the appendix of this paper.

 

Allogeneic and autogolous stem cell therapy combined with physical rehabilitation: A case report on a chronically injured man with quadriplegia

Abstract:

Background and Purpose: Stem cell therapy for SCI is a potentially promising treatment with increasing interest. This case report describes the use of a particular stem cell therapy protocol for a patient with chronic spinal cord injury, and describes his subsequent therapy and outcomes.

Case Description: The patient is a 29-year-old male who is chronically injured from a cervical spinal injury, resulting in quadriplegia. The patient was treated with a combined protocol of intrathecal (IT) and intravaneous (IV) allogeneic MSC and CD34+ cells and IT autologous BMMC at 6 ½ years post-injury. The results track the patient’s physical therapy progress until 6 months following stem cell treatment.

Outcomes: Recovery of strength in upper extremity and lower extremity muscle groups was noted, along with a functional increase in grip strength, ability to ambulate with assistance, and a significant decrease in daily medications.
Discussion: This case supports further investigation into treatment of chronically injured SCI patients with stem cell therapy followed by physical therapy.

Manuscript word count: 4321

A few highlights:

“After the patient underwent the stem cell treatment and returned to outpatient physical therapy in his hometown clinic in the United States, his MMT scores were tested over the period of 5 months post-stem cell treatment…. The patient did not decrease in strength in any of the muscles tested, and experienced improvements in 6/13 upper extremity muscle groups, and 8/9 lower extremity muscle groups.”

“The patient also had an increase in grip strength. His grip strength was measured by his occupational therapist to be 5 lbs on the right and 25 lbs on the left at one month before his stem cell treatment. Six months later, his grip strength was measured to be 22 lbs on the right and 36 lbs on the left. The patient reported that this increase in grip strength led to functional improvements, such as being able to self-catheterize, which he was completely unable to do since his injury.”

“The patient was also able to ambulate for the first time in 5 years at approximately 4 months after finishing his treatment. He was able to ambulate in partial weight bearing with the harness and max assist of two for 40 yards at .5 MPH.”


The original post on Daniel Leonard’s blog can be found here.

Jorge Paz MD: Adult Stem Cell Therapy for Arthritis, Sports Injury, and Autoimmune Disease || 3 of 3

Stem cell therapy for osteoarthritis using adipose (fat) stem cell. Case study of 76 year-old man with osteoarthritis in his knees. Stromal vasular fraction treatment statistics including side effects collected over 800 infusions. Stem cell treatments for sports injuries and why pro sports stars are seeking treatment. Case study of a professional dancer with knee and neck problems who returned to competition after stem cell treatment in Panama.

Stem cell treatment in Panama benefits autistic Glenburn youth

Autism Stem Cell Patient Ken Kelley

As Kenny Kelley of Glenburn awaits an infusion of adult stem cells at a Panamanian city in November 2011, a Panamanian physician holds two syringes containing the cells. Autistic since birth, Kenny has undergone several such infusions since 2009.

As Kenny Kelley of Glenburn awaits an infusion of adult stem cells at a Panamanian city in November 2011, a Panamanian physician holds two syringes containing the cells. Autistic since birth, Kenny has undergone several such infusions since 2009.[/caption]

By Dale McGarrigle, Of The Weekly Staff
Bangor Daily News
Posted Sept. 14, 2012, at 12:17 p.m.

GLENBURN — Now Kenny can read.

Kenny Kelley can now also do many things that other 11-year-olds take for granted. According to his mother, Marty Kelley, that’s because injections of adult stem cells, taken from umbilical cord blood, have helped Kenny to shake off the shackles of autism, with which he was first diagnosed at age 2.

“The results from stem cells can be seen everyday in his amazing thoughts and vast imagination!!,” Marty Kelley wrote in her blog, http://www.kensjourneytorecovery.blogspot.com/. “How lucky we are for such a miracle treatment!”

Autism is a brain disorder found in children that interferes with their ability to communicate and relate to other people. Autism affects 1 in 88 children and 1 in 54 boys. What causes autism has not been established.

Stem cells are the body’s internal repair system and can fix and replace damaged tissue. These unspecialized cells are a blank slate, capable of transforming into muscle cells, blood cells, and brain cells. Stem cells can also renew themselves by dividing and giving rise to more stem cells.

Stem cells taken from umbilical cord blood, such as Kenny received, are the least likely to be rejected.

The stem-cell treatment is the latest effort by Marty and her husband, Donald, to find ways to improve Kenny’s life. The Kelleys also have two other children: Philip, 13, and Caroline-Grace, 6.

First was in-home treatment in a mild hyperbaric oxygen chamber, three hours a day equaling 800 hours over the course of two years, beginning when Kenny was 5 ½ to 6 years old. This was coupled with a Specific Carbohydrate Diet, which restricts the use of complex carbohydrates and eliminates refined sugar and all grains and starch from the diet.

“We saw results right away with the chamber,” Marty recalled in a recent interview. “He made slow gains, such as tracing the alphabet.”

Then the Kelleys discovered on the Internet the story of Matthew Faiella, a New York boy who has been making great strides after stem-cell treatment in Panama for his autism. They decided to follow suit.

Why take this path, when there has been little scientific research into the use of stem cells to treat autism?

“We were willing to do it as long as it’s safe, and I’ve researched this,” Marty said. “Stem cells are very natural. I’m not a scientist, but I care much more than any scientist would, and I would never do anything to hurt my baby.”

When Kenny went for his first stem-cell treatment in July 2009, at the Stem Cell Institute in Costa Rica, Marty assessed the condition of her then 8-year-old son in her blog http://www.kensjourneytorecovery.blogspot.com:

• Behavior: Screaming, aggressive, giggles/silly/inappropriate with his brother or new people, running around, destructive, uncooperative while being dressed, hitting, not potty trained (still wearing diapers).

• Speech: Vocabulary of a 4-year-old. He can talk, but it is difficult for strangers to understand him. Answers some questions, but he does not understand or like why, when, or how questions.

• Physical: A body the size of a 5-year-old boy.

Kenny has had stem-cell treatments in 2009, 2010, and May and November of 2011. The repeated treatments are required because adult stems cells will work repairing cells for a period of time, about six months, then leave the body.

“When I think I’ve seen his skills level out, we’ll go for another treatment,” explained Marty.

What are some of the changes that Kenny has undergone in the past three years? First came the ability to read and clearer speech.

“When he got back, he just picked up a book and started reading, and I could understand every word,” said Mike Hughes, Marty’s brother. “It was like a light just turned on.”

Other gains: Kenny is talking about past events for the first time, and he’s conversational now. He expresses opinions and looking ahead to the future. He was finally potty trained at age 9. He’s doing math now. He’s calmed down considerably. This summer, he went to summer camp, staying overnight for three nights, in the same cabin as Philip.

“There’s no doubt in my mind how much he’s progressing,” Marty said. “We’re working on catching up right now, and how do we best do that?”

The costly treatment, which isn’t covered by insurance, hasn’t been approved yet by the Food and Drug Administration. Despite the fact that the stem cells come from the human body, the cells are considered a new drug by the FDA and are subject to stringent research and testing that can take years.

So this leaves the Kelleys and others like them seeking stem-cell treatment, going overseas to get it.

“It’s just a matter of how much are you going to spend,” Marty said. “There’s no treatment here that was going to do this much for him.”

Mesenchymal Stem Cells Stop Arthritis in its Tracks – Duke University

Researchers at Duke University announced a promising new stem cell therapy aimed at osteoarthritis prevention after a joint injury.

The probability of developing arthritis after injury (post-traumatic arthritis – PTA) greatly increases after injury. Currently, the US FDA has not approved any drugs that slow or eliminate the progression of PTA.

However, at Duke researchers are beginning to confirm mesenchmal stem cell (MSCs) therapy in arthritis treatment. The treatment is similar to that which professional athletes and others have been seeking abroad in places like Panama and Germany for the past few years.

Ref: Pro/Am Dancer is “Dancing with the Stars” Again After Stem Cell Therapy in Panama

In the study, mice sustaining fractures that commonly lead to arthritis were treated with MSCs. “The stem cells were able to prevent post-traumatic arthritis,” said Farshid Guilak, Ph.D., director of orthopaedic research at Duke and senior author of the study.

The study was published on August 10 in Cell Transplantation.

Lead author Brian Diekman, Ph.D said the scientists observed markers of inflammation and noted that the stem cells affected the joint’s inflammatory environment following injury.

“The stem cells changed the levels of certain immune factors, called cytokines, and altered the bone healing response,” stated Diekman.

The Duke team used mesenchymal stem cells isolated from bone marrow. Bone marrow stem cells are very rare; making isolation difficult and requiring that the isolated cells be cultured in the lab under low-oxygen conditions.

“We found that by placing the stem cells into low-oxygen conditions, they would grow more rapidly in culture so that we could deliver enough of them to make a difference therapeutically,” Diekman said.

A richer source of mesenchymal cells is adipose (fat) tissue. Therapeutic doses of MSCs are routinely harvested from fat tissue and do not require culturing in the lab. However, it does takes 5 five days to thoroughly test the adipose cell samples for aerobic bacteria, anaerobic bacteria and endotoxins.

Ref: Stem Cell Therapy for Osteoarthritis

Why does fat (adipose) stem cell therapy take more than one week?

Intravenously administered adipose-derived stem cells will tend to migrate back to the fresh wound site if it is not given an adequate time to heal. Therefore, it is essential to allow about one week after the mini-liposuction before administering any stem cells intravenously. Otherwise, there is a likelihood that the treatment will not be as effective. Additionally, it takes 5 five days to thoroughly test the adipose cell samples for aerobic and anaerobic bacteria as well as endotoxins.

In order to ensure that no patient receives an infected sample, at least 5 days must transpire before the cells can be confirmed safe and injected back into the patient.

Lastly, this 5-day waiting period enables our scientists to culture a small sample of each patient’s stem cells in the lab to observe how they are likely to proliferate once they are inside the body. If a patient’s cells show low viability, Stem Cell Institute doctors will supplement the treatment with additional cord-derived cells to compensate. The same can be done in cases of low cell yield.

Twins’ family coping with cerebral palsy

ASHLAND — Three-year-old twins with cerebral palsy are making life adventurous, challenging and bittersweet for the Hancock family.

“They’re happy kids but it definitely makes it more difficult because as a parent you want them to have every opportunity that every other child has,” said mother Carrie Hancock. “It’s hard, but we’re handling it the best we can.”

Because they were born 10 weeks premature, both children suffered developmental delays.

By the time Tessa and Dylan were 20 months old, Tessa had been diagnosed with cerebral palsy, a permanent disorder that affects movement and posture. At that time, parents Carrie and Jeremy were getting ready to take their daughter overseas for a stem cell transplant, a procedure that would allow Tessa to live a better, less physically restricted life.

In the midst of their planning, the family was soon faced with another obstacle. That January, Dylan also was diagnosed with cerebral palsy.

“What do you do? They’re your babies. You just go with it and do what you think is best,” Carrie said. “Before, we were always told that he just had developmental delays, but as much as you hated to hear it, it was almost a blessing because we were paying out of pocket for him because he hadn’t been officially diagnosed.

“That’s the silver lining I guess and now we’re able to get him the help he needs.”

The Ashland family ended up taking Tessa to Panama City, Panama, where she had her first round of stem cell treatments in 2009.

“She did really well and had a lot of improvement with her vision,” Carrie said. “Her tone in her hand had decreased and she wasn’t fisting all the time. When we went back in July, we took both the kids.”

The results were remarkable.

“As soon as we took him, he was like a whole other kid,” Carrie said of Dylan. “He was babbling and it helped him in so many different ways. He also just walked independently a couple months ago. For Tessa, it made her stronger. She was already smart and attentive.”

Today the twins attend therapy sessions at MedCentral Pediatric Therapy one day a week and preschool at Tri-County Preschool four days a week. They receive occupational, speech and physical therapy.

“A typical day for us includes them going to school a little after 8 and they’re picked up a little after 11,” Carrie said. “After we get them home and fed, Tessa goes down for a nap and then Dylan stays awake and I get alone time with him, which is nice. We work on walking and sitting up with them, but try to incorporate it into their play. We try to make it a fun time.”

The family takes the twins on outings by stroller and enjoy their play time together, but each day can be daunting.

“The biggest difference is the physical challenge of dressing and feeding. Tessa is in the process of being potty trained, but Dylan doesn’t want to yet,” Carrie said. “She can’t feed herself and we’re still changing diapers at age 3.

“Dylan’s not walking. If you ask him to pick up something, he doesn’t understand. It’s challenging.”

Recently, Dan and Stephanie Kreisher, of Ontario, held their third fundraiser for the family. Jeremy was on Dan’s 1994 state championship baseball team at Ontario High School.

The Kreishers and friends raised $1,400 for the Hancocks, along with providing them two iPads for Tessa and Dylan after learning the electronics would help their communication skills. The iPads were sponsored by Elite Excavating and Zara Construction.

“We have so much and are so fortunate that we wanted to help others,” Dan said. “Jeremy and Carrie are such positive people. They’re the happiest parents, just very admirable people.”

The feeling was mutual.

“I can’t say enough about Dan and Stephanie. The iPads are huge for us. We’re in the process of getting different communication devices to help with fine motor skills,” Carrie said. “They use them in school and it’s nice to be able to incorporate what they’re learning at home. Life isn’t easy, but we are very blessed.

“The best way to describe our family is that we’re taking the scenic route. We’re taking the back roads. We’ll get them there, but it just might take a little longer.”