$1 Million Gift for Stem Cell Research

The University of Rochester Medical Center just received the largest private donation ever from a Brighton couple to put toward stem cell research.

The couple, Jack (founder of Erdle Corp. in Henrietta) and Norma, did not indicate what variety of stem cell research the donated funds, an sum of $1 million dollars, should be used for.

Prior to Jack’s gift, UR had received some contributions towards stem cell research, but the quantity of donations were not many and each individually were not of a significant amount stated Peter.

Stem cells are the building block cells of all our organs and tissues.

The university inquired about the prospect of Jack contributing; so he went to his wife to see how she would like the money used. She quickly gave her answer.

The couple also donated $1 million to the Rochester Institute of Technology in 1998.

Jack’s company, which he started in the mid-1950’s, makes parts for electrical systems in computer, trains, and airplanes.

“I think there are so many diseases and sicknesses that could be helped with stem cell research — diabetes, Alzheimer’s, Parkinson’s, people who are paralyzed,” said Norma. “Just think how wonderful it would be, the lives we could save.”

The National Institutes of Health have given more than $40 million to The University of Rochester Medical Center to pursue stem cell research that may lead to cures for leukemia, multiple sclerosis, and spinal cord injury.

For the institute, the principal focus has been on animal and adult stem cell based research, as well as stem cells taken from umbilical cord blood due to the federal ban on funding new embryonic stem cell lines.

The NIH mandates that any federally funded programs share no resources with independently funded embryonic research, thus there is a possibility that the university may use a portion of the $1 million to produce the proper environment for research. Peter hopes the couple’s gift will encourage other philanthropists to also donate to stem cell research.

“Downstate medical centers have received millions,” Peter said about their stem cell donations, adding:

“It’s good Rochester is now in that company as result of Jack and Norma’s gift.”

Hope for Paraplegics, Stem Cell Therapy in India Delivers Results

Seven months of stem cell therapy has brought sensation back to a man who was left a paraplegic on December 26th, 2004, after his spinal cord was damaged during a road accident.

“Before operation, there was no sensation. Now I am feeling the sensation and am able to get up a bit on my own,” says 28-year-old man.

He is one of a dozen other people at the Global Hospitals in Hyderabad, India, who are undertaking stem cell therapy for spinal cord injury. The program is run under ICMR-approved protocol.

G.P.V. Subbaiah, who is an orthopedic and spinal surgeon, said that the result so far has been beyond his expectations. He was astonished by the display of such “encouraging results” in the 28-year-old patient. In January, the man was the first patient to be injected with adult-stem cells at the site of injury in the spinal cord.

Subbaiah said the patient had absolute loss of feeling from the chest downwards.

“Now he has regained all sensations, including light touch up to the groin. He also has increased sweating which is controlled by the autonomic nervous system. This shows that the system is also responding.”

Another accident victim from Saudi Arabia who flew to the hospital for stem cell treatment had regained some movement in his legs.

“Before the advent of the stem cell therapy, there was only supportive treatment to prevent bed sores and other problems like urinary infection,” said Dr. Subbaiah, “but now there is hope that some of the lost functions can be restored.”

Data from animal studies provide enough evidence that the therapy does work said the doctor.

Indian Spinal Injuries Center approximates that at least one lakh, or one-hundred thousand, spinal cord injuries happen each year. Due to the lack of proper data, this number may be grossly underestimated. Individuals from the age of 25 to 40 make up 85 to 90 percent of the spinal cord victims.

In their most productive years these injuries crippled them.

“It has a lot of impact on society,” he stated.

Adult Stem Cell Therapy Holds Great Promise for Man with Ailing Heart

Richard has congestive heart failure. This disease affects his heart’s ability to pump sufficient blood to suit the body’s daily needs. Ultimately, the disease will progress to the point where the heart becomes weaker and weaker to a point of failure. That is why on August 16th, Richard a Braselton resident, and his wife Terre will fly to Thailand to receive stem cell therapy in Bangkok.

“I’m just weak, tired, and short of breath all the time,” Richard said. “I constantly have to monitor my blood pressure and my heart rate. All the medications, there’s no end to it.”

Outside of prescribing blood pressure medications, Richard’s doctors told him that there was nothing they could do when he was diagnosed in January. Angered by the lack of options they were presented with, Richard and Terre began to explore alternative treatment options. Their search finally concluded in Thailand, where a Bangkok-based biotechnology company will provide treatment for Richard using a relatively new medical procedure, utilizing adult stem cell therapy.

Richard’s own stem cells will be multiplied after doctors extract cells form a half pint of Richard’s blood. Later, doctors will take the newly multiplied stem cells and re-inject them into Richard’s ailing heart. He should experience less chest pain and greater strength in his daily living once the cells start to take effect, about a month or two following the procedure.

After performing the procedure on over 120 patients over a period of two years, the company claims a success rate of 80 percent. 11Alive, Paul Harvey, and the 700-Club have all joined in support of the treatment, touting “miracle” recoveries on their respective programs. The company’s website has these video news segments available for individuals to watch online as well as news of patients testifying before the congress about the benefits of adult stem cell therapy.

All this and there is still a poor understanding about the technicalities behind stem-cell led repair. Researchers see a result but question the process after stem cell are injected into an injured area of the body.

Adult stem cells hold the most potential at the present time. The course that future research will take has much to do with the ethical clash that is occurring over the use of embryos. The issue has now left the floor of the congress and has entered the lives of average people.

For Richard and Terre, the very fact that stem cells work trumped the need to know what manner the cells actually work in.

The advice that Richard should focus primarily on keeping his blood pressure down did not make neither him nor his wife very happy.

“We just didn’t expect that answer, that there’s nothing we can do,” Terre said. “This is just not an option for us.”

Terre began looking into the program in Bangkok after a family member heard of the treatment and told her. She spoke with several patients of the company along with a few company representatives after looking over the website. Later she learned that one of her co-workers knew someone who had successfully received treatment as well.

Three months ago, Richard was accepted into the program. Once they reach Bangkok, they will stay there for 20 days to tour the area before and after the procedure. The couple will pay $32,500 in cash for the “medical tourism” trip; this will cover the expenses completely minus the price of airfare.

They feel comfortable that they know enough about the non-US based company and stem cell therapy stated Terre.

“There’s no downside to this,” Terre said. “We don’t have any questions, we don’t have any concerns. We realize there are risks, but with an 80-percent rate of success, it’s a risk worth taking” (20-percent of those receiving the therapy experience no change — positive or negative — in their condition).

“I’ve got nothing to lose,” Richard says. “Rather than live a bad life like I’m living and doing nothing, I’d rather take chance and get something done.”

“It’s not a lot of money,” Terre says, noting that the price is “a really minimal cost when you’re talking about saving a life.” “A lot of people who are sick and trying to exercise other options are going to be able to find that money.”

“It’s costly, but it’s worth your life, I guess,” Richard said.

Impressed by the new technology, particularly the advancement in adult stem cell treatment, Richard and Terre are optimistic about the future of adult stem cell therapy.

“It’s going to be the coming way of medicine,” said Richard. “It’s gotta be, because it’s pretty strong.”

“This could eradicate cancer,” Terre said. “It is my personal opinion; the future of medicine is going to be stem cells. There’s no doubt in my mind.”

The company performing the procedure on Richard claims that once the stem cells are placed in the area of the heart that they, “have the potential to build new blood vessels and heart muscle.”

The theory is that the stem cells improve blood flow to the heart by regenerating or “revascularizing” functional blood vessels. The cells may also act as “scaffolds” which offer mechanical strength to the heart at a occasion when it is weak, or even promote the heart to release chemicals for repairing itself.

The jury is till out on how the stem cells help, but only vast potential seems to exist says Dr. Samuel, a cardiologist with Emory University. A major advantage of the therapy is that the patient receives his own cells, thus negating any type of immune response that could neutralize the therapeutic benefits of treatment making it less effective. Future research will lead to the transfer of adult stem cells from one body to another. This would allow for immediate injection at hospitals that would keep stem cells ready.

Presently in the United States, only clinical trials are permitted, but in five years the treatments “could definitely be translated into a pure clinical product,” states Samuel.

The couple commented on their opinions about embryoinc versus adult stem cells. With no ethical dilemma, adult stem cells hold great potential alone and thus they both choose to promote adult stem cell therapy as opposed to embryonic.

“My opinion is the American public is not educated,” Terre said. “These are your own stem cells; this is your own blood.”

“If we could just get over the hump of educating all Americans. It could be their son or daughter’s lives that we could save.”

Stem Cell Trial Proves Successful

In a ground-breaking trial at a Shropshire hospital, patients with complicated bone fractures are being helped to evade permanent disability.

Oswestry’s Robert Jones and Agnes Hunt Orthopedic Hospital is conducting the stem cell therapy research.

The trial is set to involve 40 patients total and twelve have taken part thus far.

The trial involves using a patient’s bone marrow to literally reproduce their own bones in an attempt to assist the fracture and the healing process.

Faced with having her leg amputated after suffering a complex fracture in a fall down a set of stairs, Warwickshire mother Jane is one patient who will be gaining from the trial.

After suffering five years of pain and undergoing 15 separate operations, Jane, from Bidford-on-Avon was told the only alternative was to have the limb amputated.

“I realized that I would go through a lot of emotional and mental anguish,” she said.

She can lead a full life again now that the revolutionary treatment has saved her leg.

The treatment is unlike embryonic stem cell treatment, involving the use of stem cells from the patient’s bone marrow. The cells are then stimulated in a laboratory, implanted back into her leg, and therapeutic benefits are achieved.

The stem cells help knit the fracture site together by growing new bone.

“These patients have already had several operations on fractures that haven’t healed over several years and are facing amputation or a lifetime of pain and disability,” Paul a clinical scientist at the hospital said.

“Having just completed the tenth stem cell implant, the initial results are extremely encouraging. In fact, three of our patients have already handed back their crutches.”

Thailand Breaks New Ground – Plans Stem-Cell Therapy

For the first time in the country, Thailand is planning to conduct clinical trials to treat three major neural diseases confirmed the Prasat Neurological Institute.

“Well, actually, we have started,” Dr. Maiyadhaj, the director of the institute told the annual academic conference of the Department of Medical Services, held in Bangkok from Tuesday to Thursday.

Maiyadhaj explained that the procedures entail transplanting developed stem cells into the patients’ central nervous system. The trials will aid victims of stroke, spinal cord injuries, and Parkinson’s disease, with the project anticipated to commence this year.

Related studies from all over the world are currently being evaluated and assessed by Maiyadhaj and his team of 12 neurological and stem cell experts.

The institute’s ethics committee must endorse the project proposal that is at present being drafted prior to the start of patient trials planned for later this year.

The proposal includes a 10 million baht budget requirement for the first year, or roughly 270,000 in United States currency.

Ahnond, the secretary-general of the National Research Council of Thailand, confirmed that the Mahidol University’s cell engineering and tissue growth laboratory will develop the appropriate type of stem cells for the project.

“Don’t hold your breath, we’re just at the beginning,” said neurosurgeon Smarn of the Prasat Neurological Institute. “Though the efficacy of stem-cell transplant remains uncertain, it’s proved to be safe so far.”

Neurologist Akravudh, also from Prasat Neurological Institute added that neural organs like nerve cells are the most difficult to handle, contrasting other parts of the body.

“And the idea of replacing damaged human organs with new man-made ones cannot apply to the nervous system. The only way so far is stem-cell therapy,” he said.

Akravudh said that tumors were the most feared side effect of a stem cell transplant, since there is a possibility the transplanted cells could grow uncontrollably.

“With Parkinson’s we’re determining whether to grow dopaminergic neurons outside and then inject them into the patient’s bodies, or inject premature cells and then program them to become the proper nerve cells later,” Akravudh said.

Stem-Cell Therapy: The All Encompassing Cure?

Science fiction was once the genre that best fit stem cell therapy. But for patients suffering from conditions as varied as cancer, heart disease, broken bones, and paralysis, stem cell therapy may soon become science fact.

Stem cells are the building blocks of our bodies that have not yet been assigned special tasks. Think of them as blank microchips before they have been programmed. Stem cells can turn into a variety of different cells, from a heart cell to a nerve cell; given particular chemical signals they can be transformed into anything.

Adult stem cells exist in a wide range of tissues including bone marrow, muscle, the brain and liver. They are already halfway down the career path to becoming a certain type of cell.

Around 600 clinical trials are presently underway worldwide involving stem cells. The UK looks to be a center for more research and may perhaps even set the pace for everyone one else.

New uses for stem cells include treatment for diseases that are major killers and cause long-term disability. For instance, bone-marrow transplants, used for some time as a treatment for leukemia, may soon be replaced with stem cell therapies. Other potential uses of stem cells range from creating new faces and hair, to growing sperm, building replacement limbs, growing new heart cells, and growing new retina tissue for the visually impaired.

Bones
Splints and bandages or casts remain the status quo as treatment for broken bones. This has not changed for many centuries. There could be a shake-up in treatment methods soon as clinical trials are underway evaluating stem cells and their capacity to mend fractured bones. Researchers are looking at the notion of repairing fractures with stem cells and as a growth factor to accelerate bone healing. Osteoporosis, which causes brittle bones, is also a prospective candidate for therapeutic stem cell treatment. Eventually leading to osteoporosis, bone loss exceeds production as we age. Stem cell therapy could restore the balance.

Heart disease
Used in trials to tackle the damage caused by a heart attack, stem-cell therapy is already producing results as well as demonstrating the potential to grow new blood vessels to get around blockages. In the UK, almost three million people have heart disease. Limiting the quantity of damage, growing new heart muscle, and increasing the pumping ability of the heart is the idea behind administering stem cell injections after a heart attack. A second goal, a so-called grow-your-own bypass, involves injecting stem cells to grow new blood vessels and re-route blood and oxygen around damaged areas of the heart.

Plastic Surgery
Stem cells have the potential to make radical changes in this area. Already used on a small number of patients, researchers hope that stem cells can be injected on to specially shaped scaffolds in order to help fill defects in the face. Stem cells taken from the hip bone to close the bone defect in cleft palate is also being investigated by dental researchers at the University of Brescia in Italy.

Dental
The most tantalizing image of stem-cell potential in dentistry is growing teeth, however changes are closer in other areas. Nippon Dental University researchers in Japan have shown that injecting stem cells into the area where a tooth has been extracted can strengthen the bone and support surrounding healthy teeth, while Orthodontists in Naples have found they can get stem cells from dental pulp in extracted molars.

Brain Injury
There is currently no therapy to reverse the effects of brain injury, but studies on animals have shown that stem cells from bone marrow can improve outcomes. Around one in four children who suffer brain injury die as a result. A clinical trial involving children aged five to 14 with a serious head injury has begun at the University of Texas. The hope is that the stem cells will help with repairs. Within 36 hours of injury, the children will be given injections of stem cells to see how it affects their recovery.

Rheumatoid Arthritis
Rheumatoid arthritis, where the immune system attacks healthy tissue, has been treated with stem-cell therapy. Around 700 patients have been treated with stem cells for this illness along with other autoimmune diseases. In this therapy, the old marrow is removed, chemotherapy is given to zap any remaining cells, and stem cells are used to build a new immune system. Research at Leiden University in Holland shows that in about one in three cases, remission has been achieved. Immunologists in America have reported the first case of a woman being treated with stem cells from her sister as opposed to most cases, where the patient’s own cells are used. The 52-year-old was in remission and not needing any drugs only a year after transplantation.

Cancer
Cancer is the disease against which stem-cell therapy has been most widely used. Leukemia treatment is especially important, as success depends on getting rid of cancerous white blood cells and replacing them with healthy ones – usually achieved through a bone-marrow transplant. With more than 400 clinical trials under way, the use of stem cells to tackle cancer has been extended, almost every kind of malignancy is being looked at. In many of the trials, those cells that are killed by the use of chemotherapy are replaced with stem cells.

Diabetes
With type one diabetes, which usually develops in childhood, the body does not produce its own insulin and daily injections are needed. The aim of stem-cell therapy is to replace those insulin producing immune cells that have been destroyed by the body’s immune system. Patients are being given chemotherapy and then infused with stem cells from bone marrow in a trial being run by Northwest University in Chicago: “We hypothesized that reprogramming the immune system will stop immune aggression to the insulin-producing cells, allowing their regeneration,” say researchers.

Paralysis
Superman actor Christopher Reeve, paralyzed in a horse-riding accident, was one of the leading campaigners for stem-cell research. Scientists are reporting success with small numbers of paralyzed patients, although large clinical trials are still in the future. The idea behind the therapy is that the stem cells can grow into nerve cells to replace those that are permanently damaged, and bridge the gap between the severed pieces of the spinal cord. Researchers in Argentina are reporting the restoration of movement in two patients.

Crohn’s Disease
Thought to be caused by immune cells attacking tissue, Crohn’s disease is a bowel disorder. A trial is looking at the use of chemotherapy followed by an infusion of the patient’s own stem cells. “The purpose of the chemotherapy is to destroy the immune system completely. The purpose of the stem cell infusion is to restore the body’s blood production,” say Northwestern University researchers.

Multiple Sclerosis
In MS, myelin, the protective coat that surrounds nerve cells, is damaged or destroyed by immune-system cells. The aim of stem-cell therapy is to use chemotherapy to destroy the malfunctioning immune system, and repopulate it with stem cells. A pilot study found that 18 of 19 MS patients stabilized or improved after treatment, according to the US National Institute of Allergy and Infectious Diseases and the Immune Tolerance Network, who are sponsoring one trial.

Neurological
Parkinson’s and a number of other neurological diseases have hope in stem cell therapy. To replace cells lost to the disease, the idea is to coax stem cells into becoming dopamine-producing nerve cells. The treatment being explored is transplanting stem cells into the target sites of the brain that need dopamine. Dopamine is a chemical that allows messages to be sent to the parts of the brain that co-ordinate movement. Animal studies are under way.

Robotic Surgery Techniques Deliver Stem Cells – Cardiac Cell Therapy Research

Researchers effectively used robotic surgery to deliver stem cell treatment to damaged heart tissue in pigs at the University of Minnesota.

The robotic surgery apparatus was minimally invasive throughout the injection procedure. The researchers took an extra step and “marked” the transplanted cells with iron particles in an effort to see if they engrafted in the pig hearts.

In six of seven cases, the transplant process was successful. The cells took hold and enhanced functioning of the heart as following MRI studies showed.

The cells that give rise to muscle, also know as myoblasts, in combination with bone-marrow derived cells were used in the experiment. Improving the development of new blood vessels as well as the performance of injured heart muscles were key characteristics confirmed by the implantation of both cell types. Both are in human clinical trials as well.

The research is available in the current issue of the Journal of Thoracic and Cardiovascular Surgery.

The method could be applied in human clinical trials once additional animal studies are completed.

“In people with heart failure, open surgery can be risky; finding a minimally invasive technique to deliver cell therapy to the damaged cardiac tissue would reduce the risk to patients,” said Doris, Ph.D., professor of Physiology, holder of the Medtronic Bakken Chair in Cardiovascular Repair, and co-leader of the study.

The minimally invasive approach would present several benefits for people with heart failure, Doris said. It offers surgeons the capability to target the cell infusion more precisely by utilizing a magnified view of the heart. It requires less time under anesthesia and can be performed while the heart is still beating. It is less dangerous to the patient.

Harald, M.D., co-leader of this study, now a surgery resident at Massachusetts General Hospital in Boston, pointed out, “Currently these types of cell therapies, in which stem cells are injected into damaged hearts, are only available to people who are enrolled in clinical research trials.”

Skeletal and bone marrow cells that are injected into damaged heart tissue have been shown to improve function in the left ventricle, the chamber of the heart that pumps blood into the aorta, the main artery through which oxygen-rich blood flows from the heart to the body.

Doris said more research needs to be done to establish if the minimally invasive technique can promise comparable results to open surgery, as well as which types of cells are most beneficial to infuse into damaged hearts. “But that is what keeps us busy,” she added,” finding the best treatment for patients with heart disease.”

A 70-Year-Old Poster Boy for Science – Man Saved by the Stem Cell

Mike had an angioplasty, triple-bypass heart surgery. Inside him were four wires, two stents, a pacemaker and a defibrillator. He had apparently run out of options in battling heart disease.

“After the last stent, doctors told me there was nothing more they could do for Mike,” said his wife, Marion.

However, science delivered a response. At the Minneapolis Heart Institute which is part of Abbott Northwestern Hospital, the 70-year-old Mike became a recipient of experimental stem cell treatment in January.

Different from controversial embryonic stem cell research, the treatment uses Mike’s own stem cells. Earlier this month, saying the utilization of embryos to perform stem cell research amounts to murder, President Bush vetoed a bill that would have expanded federal funding of embryonic stem cell research.

Mike said his experience has strengthened his support of all stem cell research.

“Based on what has happened to me and based on what all the medical people have told us, this will be the real answer,” he said. “Just think of the possibilities Parkinson’s, Alzheimer’s, diabetes, spinal injuries.

“It’s not to make us live forever. It’s so we can feel better when we are living.”

Mike feeling healthier is not as apparent as black-and-white. The answer is truly in color.

Looking much like a weather map does with heavy storm activity; Mike shows colored images of his heart at his Riverside Park home. The dissimilar colors show the health of the different areas of his heart. Pink areas are the healthiest and brown areas are the worst.

Before his January treatment the map only displayed a hint of pink and a big brown area. At his recent six-month checkup, the brown has all but vanished and practically a third of his heart is fully pink.

The map confirmed what he already knew. “I have more stamina,” he said. “I just feel better.”

He knew his results were good for another reason, too. He was asked to offer a testimonial about the experimental research. His words and full-page photograph grace the professional brochure the institute uses to seek donations.

“I figured it was working because they wouldn’t ask a guy who wouldn’t be around when the brochure came out,” he said.

Mike’s treatment took only a few hours and one overnight stay, which was of no cost to him because the procedure is experimental.

The treatment had bone marrow cells drawn, treated and then injected into 15 ailing portions of the heart. The presumption, according to lead researcher Dr. Tim, is that bone marrow cells stimulate the growth of blood vessels. The researchers also use stem cells to grow new muscle in the heart in a similar study.

Mike has an enlarged heart that wasn’t getting adequate blood. More vessels improve the blood flow in the heart, thus making it healthier.

“Mike had blockages that you couldn’t fix with bypass or angioplasty,” Henry said. “Whenever he does any work, he has shortness of breath or pain.”

With Mike’s results just one example of the success, the doctor said the research looks promising. Although Tim said the research is “cutting edge,” the theory is quite simple.

“We’re constantly repairing our own body, whether it’s our blood vessels, skin or liver,” he said. “So using our own cells, this is the natural way that the body rebuilds itself.”

As a poster boy for cutting-edge science, Mike feels odd. After all, he’s lived a life of routines. For 37 years, he’s lived in the same home. He has moonlighted the last 25 years as a public address announcer at high school hockey games. He worked 36 years as a post office carrier before retiring in 1993, partly for health reasons. He and Marion are a week shy of their 52nd anniversary.

He’s widely known as a practical joker and someone whose happy, optimistic persona spreads cheer. He spends much of his retirement following his three granddaughters in their year-round athletic pursuits.

“Being part of this research is like winning the lottery,” he said. “What a lucky chance I got. I am just going to continue on like a ball of string unwinding into the future.”

He has lofty praise for his local doctors. He feels equally lucky with his other medical treatment in Grand Forks since the 1987 heart attack suffered while delivering mail.

“There’s always been some new procedure, new medication or new idea for me,” he said. “I’ve never had a bad experience in a hospital. I’ve always looked forward to going to my doctor appointments.

“When I went to the hospital in Minneapolis, I figured they’d fix me up again. And they did.”

So, he doesn’t require catnaps as before. For the first time in at least five years, he is mowing the lawn. A struggle to walk across his lawn before, he can now walk a mile without discomfort.

“But I don’t go dancing,” he said. “Of course, I never did.

World’s First, Athens to Host Revolutionary Stem Cell Transplant

Does your baby’s umbilical cord hold a miracle?

A four year old boy will become the recipient of stem cells extracted from the umbilical cord of his baby sister who was just born last week in Athens. The boy is afflicted with chronic granulomatous disease, a congenital heterogeneous immunodeficiency disorder resulting from the failure of phagocytes to kill ingested microbes, resulting in increased susceptibility to severe infections that eventually leads to untimely death.

Being administered by geneticist Costas Pangalos and gynecologist Costas Pantos, the procedure will be the world’s first for this particular disease.

Dr. Pantos told ANA-MPA that the parents of the sick toddler’s parents also have a healthy older child. In the procedure, the mother’s ova (eggs) are fertilized in vitro. The fertilized ovaries then undergo a PGD (Preimplantation Genetic Diagnosis) to determine which fertilized ova are free of this particular hereditary disease, as well as a histocompatibility test for compatibility with the ailing child. The disease-free, compatible ovum is than implanted into the woman’s uterus.

The procedure was innovative given that no tissue or blood was taken from the infant itself, Pantos explained. Instead the treatment was of the kind where stem cells from the blood contained in either the umbilical cord or the placenta — both of which are discarded after the birth takes place — are used to save lives.

Given traditional treatment, the 4-year-old boy’s prognosis would not be good due to the fact that the disease becomes fatal when the patient reaches the age of 10-15, However, the countdown for the boy will be stopped as soon as the stem-cell transplantation takes place at Athens’ Agia Sophia Children’s Hospital in the following weeks.

In seven months’ time for a comparable reason, a second baby will be born into another family in Ilioupolis, Athens. Again, the specialized tests conducted before the in-vitro-fertilized ovum was implanted in the mother’s uterus came out exceptional like in the first case, according to Pangalos and Pantos.

According to Pangalos, this is a world-first and it is a major scientific achievement showing that Greece has great technological potential. “A single cell can provide the information that an embryo is healthy and histocompatible, a state or condition in which the absence of immunological interference permits the grafting of tissue or the transfusion of blood without rejection,” he said. “Only two or three research centers in the United States, one in France, an Italian, a German and we, have the necessary technological capability,” added Prof. Pangalos. “From now on, the greatest application of this method will be the treatment of children suffering from cancer. There are not enough donors, and unfortunately children die. This technique can save their lives,” he stressed.

Prof. Pangalos will announce this world first achievement by Greek doctors and geneticists at the American Geneticists Conference in October.

What Great News! Embryonic Stem Cells Unnecessary!

With the controversy surrounding the use of embryonic stem cells, the above headline may come as a shock. The recent veto by President George Bush that denied extra federal funding for research conducted on embryonic stem cells, along with the clamor and backlash the decision faced from scientists, politicians, and various institutions, has all but confirmed the importance of embryonic stem cells. Is that not right? Perhaps not, as commentator Pat Boone recently found out. The fact is, embryonic stem cells may not be as important as we all think.

A couple of months ago, I was in downtown Los Angeles, at the courthouse, doing my jury duty for several days. There are always breaks and lulls, during which time hundreds of participants can and do talk and get to know each other. I actually enjoyed it.

During one of those breaks, I was electrified by a conversation with an L.A. scientist/engineer/businessman named John. Somehow the subject of embryonic stem-cell research came up, and I expressed my deep concerns about the eventual creation of nascent embryos and then the use of them in laboratory experiments. The state of California recently committed 3 billion taxpayer dollars, over the strenuous objections of many of us, to this experimentation.

Boone thinks like many of us today, that embryonic stem cells hold some sort of key to all our ailments. However, the moral dilemma that many individuals have with using embryos fuels the controversy. It seems as if the only thing keeping us from making great medical strides and developing advanced and effective treatments for illnesses that are incurable, is money to do the research needed to find the answers, and the elimination of any moral and religious debate. This has been the underlying principle behind embryonic stem cell research as Boone describes.

The rationale, the hope, is that pure embryonic stem cells might be effective in treating dire conditions like Parkinson’s, cancer, epilepsy and Alzheimer’s disease. There’s no proof, just the hope and projections of eager scientists and many large medical companies, and the very understandable desire of so many whose lives are affected by these and other maladies. The yearnings to find cures, somehow, somewhere, are overriding the moral questions about actually fertilizing a human egg with a human sperm, creating a life (obviously, if the new creation isn’t living, it’s useless) – and then dissecting and short-circuiting the inevitable development of this living organism in a search for a possible cure-all.

John continued to explain to Boone what his company specialized in. Dr. John said that it was non-controversial stem cells and treatment. He told Boone about the research that they had done and in detail pointed out the differences between embryonic and non-embryonic stem cells. Boone’s commentary below shows his amazement at what he heard. Because like many of us today, he was led to believe by the media and hype surrounding embryonic stem cells, that they were the only answer and that any moral dilemmas any of us face would have to be sequestered.

John told me about his company, a Los Angeles based adult stem-cell company whose goal is to develop stem-cell products for the life science and health-care industries. He informed me that the scientific founders of this company have over 30 years of experience in stem-cell research –and that they have discovered a novel stem cell from adult tissues with properties similar to cells obtained from embryos! These cells can be – and are being – recovered from almost any tissue found in adult humans, while maintaining many of the properties described for embryonic stem cells!

I was astounded.

John went on to tell me about the research conducted all these years by Dr. H and his colleagues in laboratories in Georgia, demonstrating scientifically that postnatal individuals – that’s you and me – contain a series of adult stem cells with attributes very similar, but not identical, to stem cells derived from embryos and fetuses. The similarities between these two groups of stem cells, i.e., embryonic stem cells and adult stem cells, include an unlimited ability to increase in numbers (self-renewal) and their ability to form any cell type in the body, including the gametes.

John continued to outline the discrepancies between the two forms of stem cells, and went on to state that a person could even use their own stem cells harvested from their own body. This would be ideal since they would be an exact match for the patient right down to the very DNA, and eliminate any chance of rejection.

The differences noted between embryonic and adult stem cells are reflected in the programming of the cells. The former cells are pre-programmed to form all the tissues of an individual. This event occurs automatically after conception, with fusion of the reproductive gametes, the sperm and ovum. In contrast, adult stem cells are not preprogrammed to form anything; they wait for exterior or environmental signals to tell them what they should do. They’re in a “resting state,” in effect waiting for marching orders. And Dr. H demonstrates, in a powerful photographic presentation that my wife and I have seen, that his group can – and have – identified and utilized specific chemical agents that can tell adult stem cells to form a specific single cell type, which they will do. And then those cells can be injected into the blood stream, where they will seek and find the damaged place where they’re needed!

And, wonderfully, a patient’s own easily harvested adult stem cells can be used for his or her own treatment, and the implanted “self” stem cells will not be rejected! In the presentation Shirley and I saw, we observed these powerful cells go like homing pigeons to the most needed spots in the heart or brain or other vital organ of the donor – and repair the damage. It looked truly miraculous, and we believe it is.

Boone finished his commentary by once again discussing the moral issues surrounding the use of embryonic stem cells. But there is an alternative as Boone learned. All the benefits of stem cell therapy, without any moral issues to hold science back. Boone even cites biblical passages in the end to point out that the bible, the foundation of the morals that drive many to oppose embryo use, may have been trying to tell us what all along what now seems to be an answer.

We’re not doctors or scientists and can only partially grasp all we’re seeing and hearing about. But to us, what these qualified and experienced scientists have discovered and developed not only makes the very expensive, long-range and extremely questionable research and use of created embryos unnecessary, it also offers help and probably miraculous treatment much more imminent and abundantly available, without the moral dilemma.

It reminds me of the time Moses balked at God’s command to confront Pharaoh with His command “Let My people go!” Moses felt so inadequate and asked, “Why should Pharaoh listen to what I say?” And God answered, “What is that in thy hand?”

Moses, befuddled, said, “My staff, my walking stick … Why?” God told him to throw it on the ground, and it became a serpent. Then God told him to pick it up, which Moses gingerly did, and it was a staff again. The point was the Creator of all mankind can do anything He wants, and we’re created in His image, with infinite capabilities. Instead of trying to “play God” and tamper with His proprietary creative processes, I feel we should recognize that He’s asking again, “What is that in your hand, in your blood? Use that, and I’ll work with you. Leave creation to me. I’ve got a lot more experience than you do!”