Improving Cartilage Healing with Adult Stem Cells

Recovery can be a painful and lengthy process for an individual who has injured an elbow or knee. These parts of the body are composed of the slow-healing tissue, cartilage. Tissue that is damaged or missing is often lost forever. However, this may no longer be the case. Stem cells could possibly facilitate the needed tissue replacements as researchers at the University of Guelph are hoping.

Improving cartilage healing after joint injuries with the assistance of stem cells is the hope for biomedical sciences professor Dean and doctoral candidate Thomas. Joint injuries are frequent and expensive in horses, so the duo has made the decision to begin their research with an equine focus. In regards to human joint injuries, encouraging results from their research could serve as a model for future human treatment.

Stem Cell Therapy for Boy After Near Drowning Leaves Him in Vegetative State

Slumped in a blue reclining chair, Michael sits in his father’s front room.

Underneath the teenager’s sweatpants, the fifteen year old wears powder-blue diapers.

Moving forward and to the right, his head droops, only to jerk up as Michael tries to make eye contact with others.

After traveling 9,000 miles for adult stem cell therapy, this jerky head movement could perhaps be a sign that the treatment he received is working.

Doctor’s injected stem cells several times into his bloodstream and spine while his father sat hoping for positive results in the Chinese hospital.

And even though David, Michael’s father, is afraid to hope that his son will make some sort of recovery because he doesn’t want to be heartbroken again; he is equally afraid not to.

“Believe me, when you’re in this condition, you look for any change you can,” he said.

After becoming intoxicated at a beach party with other teens, the then fourteen year old Michael drowned. He was resuscitated but the damage was done. Extensive brain damage occurred when he went without oxygen for a period between 10 and 30 minutes.

Just like Terry Schiavo was lost in a vegetative state, Michael has been locked in this persistent condition since his drowning in June of 2005.

After communicating with other parents of brain-injured children on an internet support group, David decided to look into stem cell therapy.

“Parents have to be careful. It’s your child. You’ll do anything. People will take advantage of you,” said David, who added that there are a number of alternative therapies available.

But he said that the most hope was offered by adult stem cell therapy.

“It’s not a magic bullet. On the other hand, it’s not black magic, either,” he said.

Certain stem cells therapies are being used in the United States today, however, the procedure is limited to experiments and specific diseases such as leukemia.

Since a patient receives healthy bone marrow stem cells from a donor to replace abnormal ones, a bone marrow transplant is technically stem cell therapy.

But there are no stem cell therapies available for neurological injuries such as Michael’s.

David’s internet research returned few results. He found that only three countries, the Dominican Republic, Mexico, and China, offered the kind of stem cell therapy Michael needed.

It was a mix of eastern and western medicine, and the $20,000 six-week hospital stay included fee, that made China his choice.

David and his wife of two years, Dana, flew to China with Michael in late November. It was trip made possible with money withdrawn from David’s 401(k).

Michael was in and out of wheelchairs and airline seats during the 30-hour trip. Not a simple task considering Michael is basically as David says, a “152 pound infant”.

Michael’s spinal cord was injected with four doses of umbilical cord stem cells over the six-week course of treatment. A fifth cord blood stem cell infusion was administered intravenously.

The immature stem cells should stimulate a response within the next three months according to the Chinese doctors.

“What I’m personally hoping for is in the next couple of months (that he’ll be able) to give me a yes or no,” David said. “(The) long-term goal is that he’ll come back, ‘Where have I been for a year-and-a-half?’ ” his father added wistfully.

The things that Michael can do are still more difficult to list than that things he cannot. He can’t swallow anything, not even his own saliva, so he has a feeding tube to help him through the process. None of his extremities move voluntarily, but he still has sensation in all of them.

Michael has no response when his father plays music that Michael downloaded before the accident. His eyes cannot track colors or movement.

He laughs randomly, and occasionally – heartbreakingly – cries.

Michael was plagued by a skin condition since the brain injury, but that has at least disappeared.

But it is difficult to measure more signs of progress.

David has not slept through one single night since the accident because Michael hasn’t either.

A baby monitor in his room alerts his father when Michael wakes up. He may just be awake; or it’s possible that his position needs to be shifted or that his diaper needs to be changed. Michael can’t tell his father.

David wakes up every time Michael does. His father says that Michael’s body clock appears to have been permanently injured from the brain damage.

“It would be pretty bad if he died on my watch,” said David. “Right now, it’s just maintaining him physically until the cognitive part kicks in.”

For now, David just focuses on the moment that is right in front of him – on surviving that one, and the one immediately following.

Until Michael reaches the age of 22, he will attend Silver Sands School during the day.

David and his son had talked about Terri Schiavo and how her life ended. David thinks back to those past moments on occasion.

“If you’re asking me what he would have wanted, he would not have wanted this,” David said. “But he does not have that choice.”

For now, David is looking for proof that he has gotten even the smallest fraction of his son back, evidence that the adult stem cell therapy is working.

“All we gotta do is make it through another day, another day, another day. I can’t look way into the future,” he said.

“If I look too far, I might see the truth, you know, and I don’t know if I want to.”Stem Cell Therapy for Boy After Near Drowning Leaves Him in Vegetative State

An Adult Stem Cell Answer for Alzheimer’s?

Ground breaking research was presented at the Blenheim Wesley Center on adult stem cell transplants. Dr. Richard, an Auckland University professor gave his presentation to more than 200 people.

Giving hope to those afflicted with Alzheimer’s and other neurological conditions, the pioneering brain scientist delivered his message.

Serving as a repair system by replenishing destroyed or damaged cells in the body, stem cells can divide and differentiate into other cells.

Enabling brain cells destroyed by diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, to be restored; a feasible number of adult stem cells were effectively transplanted for the first time by neuroscientists at the university. The test subjects were laboratory rats.

Dr. Richard says that this specific type of stem cell therapy is still at least another 10 to 15 years away for humans. But the 61-year-old Lily Medal winner said that a difference could be made within the next five to ten years thanks to new drugs developed from the research.

Adult stem cells are already used to successfully treat many other conditions.

Human brain tissue will be required so that the large research group can utilize the raw materials to study brain disease. " It is a cornerstone of the research that families bequeath the brains of loved ones to us so that research can continue," he said.

At one time scientists believed that new brain cells were not created in adulthood, however, a top U.S. scientific journal decided last week to publish Dr. Richard’s research demonstrating the opposite. He was elated to hear the news.

The entire audience was listening to every word of Dr. Richard’s enthusiastic presentation, "Brain Diseases and Stem Cells – Fact or Fantasy". His lecture was intended for regular individuals without a medical background as well as health professionals.

"There is a lot of interest currently in the potential future use of stem cells and gene therapies to treat many neurological conditions," he said.

"The recent demonstration of stem cells in the adult mammalian brain raises the exciting possibility that these cells may be able to generate neurons for cell replacement in neurodegenerative diseases such as Parkinson’s, Huntington’s, Alzheimer’s and epilepsy."

"Our research studies provide the first evidence of neurogenesis in the diseased human brain and are exciting findings indicating the regenerative potential of the diseased human brain."

"Our studies suggest the possibility that neural stem cells in the adult human brain may provide a means for the application of novel new treatment strategies involving cell replacement techniques in the treatment of patients with brain diseases."

"However there is still considerable research to do before these exciting findings can be applied to the treatment of patients with neurological diseases."

Naples Man Fights Against Heart Failure with Aid of Stem Cells

Another seven or eight months, and Mel would be dead. He was running out of time since he found no sympathy from congestive heart failure.

But then adult stem cells came into the picture, quite literally, as a potential life saving treatment. Mel’s son watched a program on The Discovery Channel about adult stem cells. They were injected to improve heart function and grow new muscle after being harvested from a person’s own blood.

The Bangkok Heart Hospital became the 72-year-old Mel’s destination of choice, since adult stem cell therapy is only in its infancy in the United States in terms of treatment and research.

Thailand became the country where Mel would receive his treatment.

“I feel 100 percent better,” Mel, a retired businessman in Naples, said. “I can walk around and do a lot of things without getting out of breath. Of course, there are a lot of skeptics in the medical field.”

Dr. Zannos, has become an advocate of the procedure; and for those who are skeptical that the procedure really had any effect, the Florida cardiologist is sponsoring a free seminar on adult stem cell therapy for heart failure.

Adult Heart Cell Found to have Same Capability as Embryonic Stem Cell

Capable of developing into all types of cardiac cells, a new cell type in adult rat heart tissue has been found by researchers at the University of Minnesota.

This gives hope for the possibility of treatments such as the growth of new blood vessels for use in bypass surgery or to repair damaged heart muscle after a heart attack. The cells could be expanded in a lab after being harvested and then used in therapy.

Appearing in the February print edition, The journal Nature Clinical Trials Cardiovascular Medicine has published the research.

The researchers expanded tissue taken from adult rat hearts in a dish after adding certain growth factors. These cells were able to give rise to all types of cardiac cells, such as the cells that make up the left and right ventricles and blood vessels. Impressively, just as more mature heart muscle cells will do, the newly grown cells even beat in a laboratory dish.

Professor of physiology and director of the Center for Cardiovascular Repair, Doris, said that they injected the cells into rats with injured hearts and documented that the cells repaired the damaged tissue.

Paralyzed Sisters Return from China After Adult Stem Cell Treatment

After undergoing experimental stem cell transfusions for their damaged spines, sisters Shannon, 21, and Erica, 18, have returned from China.

The two sisters now use wheelchairs after both being paralyzed in a 2004 car accident. With the hope of experiencing some relief from the pain they feel on a daily basis, they traveled to China for a month long duration of treatments that were not available in their home country of Canada.

They are hopeful that that treatment will have an effect, but they say it is still too early to tell. But there are signs that the stem cells have begun their work.

“I have noticed differences in my circulation and like, my legs and my feet are a lot warmer now, so that’s a positive thing,” Erica said, noting that her sister has noticed the same result.

“Hopefully, with work with our physiotherapist and stuff we’ll start seeing some more improvements.”

Their treatment involved the injection of millions of stem cells at the Shenzhen Nanshan People’s Hospital. Herbal intravenous sessions and acupuncture were also a part of the treatment.

“I was really nervous at first but they were really simple,” Erica said of the treatments.

Skin Disorders and Adult Stem Cells, Scleroderma Treated

Julian treasures every step he takes, which is in contrast to the many people who dread working out.

“It’s just really hard for me to do anything,” he says — hard because Julian suffers from scleroderma. Causing inflammation, pain, and hardened skin, his body is attacking itself throughout the skin and organs. His lungs, kidneys, and other organs could eventually fail due to his condition.

Julian is afflicted with a disease that is rare and affects only 100,000 Americans. It’s so excruciating it can disable … and even kill them.

“A bad day is typically just not being able to get out of bed, [with] no energy,” he says.

Hopefully Julian won

Woman with Brain Damage Better Thanks to Adult Stem Cells

Quita was competing at Timber Creek when she fell and sustained injuries which left her unconscious for six weeks. After suffering severe brain injury, she says adult stem cell research has helped her recover from her terrible camp drafting disaster four years ago.

The adult stem cell therapy has made an immense difference bearing in mind the fact that her doctors feared that she would not even survive.

“I feel an improvement, it’s a lot easier to move all my limbs on the horse, and just balance is a lot better,” she said.

She decided to make the trip to Germany for adult stem cell treatment with the help of more than $40,000 her family raised through various means.

Quita doesn

Scientists Investigate Adult Stem Cells Potential to Heal Diseased Heart

In order to determine if a subject

Device Harvests Adult Stem Cells, Kills Cancer Cells

Sidestepping the contentious use of stem cells derived from embryos, researchers at the University of Rochester have unveiled a new device technology that makes it feasible to harvest stem cells from the blood.

Potentially improving the prognosis for many cancer sufferers, the technology is also being developed into an anti-cancer implant that programs cancer cells to die. The technique may even produce implants that direct the body