Answer to Stem Cell Dilemma Right Under Our Noses

A neurobiologist who has spent the last 20 years of his life working in the area of neural regeneration believes that adult stem cells are the future of medicine.

During his time conducting research, Alan investigated adult stem cells for the last five years. He discovered surprising information in regard to the technological advances in the field of adult stem cell biology.

What he found shows that the potential of adult stem cells alters the political debate. For the exploration of disease and drug discovery, adult stem cells present a serious alternative to embryonic stem cells for cell transplantation.

Numerous clinical trials are being conducted throughout the world using adult stem cell therapies and substantial advances have been made. Most trials are still experimental but it has been show that the lack of embryonic stem cell use results in a decline in problems. Those include immune rejection and uncontrolled growth.

Stem cells that are multipotent have been isolated from the skin, tooth pulp, brain, fat tissue, and bone marrow. Adult stem cells have been isolated from the organ of the sense of smell in the human nose in Alan’s lab. They are related to those cells found in the brain and are referred as neural stem cells.

Alan and his colleagues have demonstrated the very broad developmental potential of adult stem cells. Far exceeding the expectations of adult stem cells with the ability only to repair the tissue origin, they have been able to induce these adult stem cells to become kidney cells, blood cells, liver cells, muscle cells, heart cells, fat cells, and numerous others.

The utility of the cells is being explored regarding motor neuron disease, spinal cord injury, and Parkinson’s disease; animal models of disease and injury are included as well.

Bone marrow stem cells are being used in cell transplantation therapies around the world by various other groups, thus, Alan and his team are not alone in using adult stem cells for the aforementioned purposes. Cardiac repair after heart attack is just one of the numerous clinical trials where bone marrow stem cells are being utilized.

After stem cell transplantation, most report an improvement in function. Obviating immune rejection issues, in many cases adult stem cells have the advantage that they can be taken from the same patient who needs repair.

Spinal cord injury treatment is another example of the developing therapies that use olfactory unsheathing cells. These specialized cells show promise fro treating spinal cord injury in animal studies. By transplanting them into the injured spinal cods of human paraplegics, Alan hope to get results while undertaking this Phase I clinical trial.

By studying embryonic stem cells and their progeny from the patients, it is often stated that therapeutic cloning will be required to investigate the biology of certain diseases and to find cures.

However, a long and laborious procedure, therapeutic cloning will produce an inexact “copy” of the donor. This is because of the handful of genes that are passed on through the donor egg. Adult stem cells provide an alternative source and answer for these dilemmas.

Relatively, easily obtained and easily grown in a lab in large numbers, Alan already has over 40 adult cell lines derived from persons with mitochondrial disease, Parkinson’s disease, motor neuron diseases, and schizophrenia.

Studying adult stem cells will illuminate knowledge of embryonic as well, but ethical issues stand in the way of embryonic cells. Taking this into regard, the knowledge of alternative technologies should not be disregarded. Adult stem cell therapy is the alternative and in many cases, superior to embryonic stem cell technology.

Offering many advantages over embryonic stem cells, it is important to keep the public and politicians informed of the developments in all the area of adult stem cells.

Knee Repair with Stem Cells Could Help Millions

Injections of bone-marrow stem cells and implanted “cartilage plugs” top the list of wanted treatments, as doctors test innovative processes to stimulate cartilage regrowth in damaged knees.

The cartilage that cushions the knees has only a limited natural ability to repair itself, thus, the knees are are the joints most likely to become problematic. The need for new and innovative treatments is great.

Unlocking the ability for accelerated self repair of the joint is the primary goal.

Those individuals who only require small amounts of cartilage to grow are the preliminary group to try the new alternatives.

The techniques, if they do indeed work, could help people with arthritis as well since their cartilage breaks down over time.

The pad of cartilage referred to as the meniscus, basically the knee’s shock absorber, is the first to be in clinical trials for this treatment. Using cells from donated bone marrow with an aim to regenerate tissue, the outcome is eagerly anticipated.

The meniscus is surgically removed in about 800,000 American’s each year. A painful tear can result in an older person with only a simple wrong step, due to the fact that the pad deteriorates with age. Thus, young athletes are not the only ones who can suffer. Meniscus injuries are commonplace in this world.

Studies have demonstrated that combining knee lubricating fluid with stem cells helps to regrow the meniscus in goats. The adult stem cells are called Mesenchymal cells, and live within bone marrow. These cells can convert into cartilage forming cells called chondrocytes. Is it possible that the cells which serve as building blocks for tissue could also work similarly in humans?

Individuals with half of their meniscus removed enrolled in the study, 55 patients total. The study consisted of a placebo injection or one containing millions of mesenchymal stem cells; these were administered one week after the meniscus surgery.

Researchers are now evaluating each patients remaining meniscus for signs of regrowth using high powered MRI machines.

“No one’s ever looked at the meniscus in terms of volume,” says Dr. Thomas of the University of Southern California, lead researcher for the study.

Preliminary results are due in October and so far there have been no safety problems. The study is still blind so researchers are oblivious to which patients were among the placebo group and which were not.

“It’s very, very exciting research,” says Dr. David, an orthopedic surgeon and sports medicine specialist at Washington Hospital Center in the nation’s capital.

Man with Congestive Heart Failure Seeks Adult Stem Cell Treatment

Powerless to catch his breath, Shelton initially became aware of the fact that his heart was straining while square-dancing one evening.

“He started getting worse and worse,” Shelton said, and he was finally diagnosed with congestive heart failure at Cape Canaveral Hospital in Cocoa Beach.

“I overheard one of my doctors talking to another doctor who said I was on a slippery slope,” and that is when the 74-year-old Merrit Island resident realized the critical nature of his heart condition. Congestive heart failure afflicts about 5 million other Americans.

His relatives felt a hospice was the best choice, a non-curative care center for those individuals whose life expectancy is not anticipated to surpass six months.

While under hospice care, Strickland read about how doctors use adult stem cells taken from the patients own blood, and through an experimental procedure treat and strengthen an individuals deteriorating heart.

Referring to the $34,500 price tag he said, “it is expensive.” The price includes treatment and accommodations for 14 days in Bangkok and is not covered by insurance. “But my kids told me: ‘Go for it.’”

He did; and in late April, accompanied by his wife, Carolyn, he left the country for the adult stem cell operation.

This is a final option that less than a projected 200 patients worldwide have searched out. This adult stem cell procedure involves injecting millions of these early-developmental cells directly into his heart. It has the potential to construct new blood vessels and heart muscle by contributing to new blood vessel development and helping to generate new tissue in the heart.

The clinic states that, “overall, our success rate is 70 to 80 percent, as measured by how the patients themselves feel” after treatment. “At least half feel markedly better; another 25 percent feel somewhat better or no worse; and 25 percent have little benefit.”

Securing a second opinion from a heart doctor in Brevard County and talking with six other heart patients in the United States who had undergone the same procedure helped him make up his mind. The doctor told him, “If it was worth anything, we would be doing it here,” Shelton recalled.

But he was undeterred, and with fluid backing up and accumulating in his lungs and other tissues of the body, Shelton had nothing to lose.

After a sequence of tests to check kidney function and his heart status, blood was drawn from his arm and the stem cell expansion process began. (An average of 20,000 stem cells are extracted during the process and then expanded up to 20 million) A week later the cells were injected directly into his heart.

“They cut a 1.5-inch incision between the ribs, and collapsed my lung, separating it from the heart,” he said. “Then they injected the stem cells into 30 different locations — into the heart muscle, the veins and the arteries.”

After a four day hospital stay following the surgery, Strickland was discharged to his hotel where he relaxed for the next few weeks.

Through surgical operation the cells are directly implanted into heart muscle or akin to an angioplasty, the reinfusion is directed through a catheter.

“Generally, those with severe coronary artery blockage get stem cells through a catheter,” doctors said, “while those in heart failure, like Mr. Strickland, get a direct injection into the heart.”

Now, approximately three months following his operation, his heart is pumping far more efficiently than it did — a doubling in his ejection fraction from less than 10 percent to between 20 percent and 25 percent — he already has been hospitalized once since his return, because of fluid accumulation around his heart again.

When asked about his progress so far he stated that, “I can change the oil in my car and put up storm shutters, but that’s about it.”

But he has been told it will be “a while” — at least a year — before the stem cells begin to fix his heart tissue, he said. And he is no longer in hospice care or on daily oxygen.

Now he follows the advice of his heart doctor in Cocoa Beach and sends back his test results to his doctors overseas every three months.

“He said: ‘Just stay active and do what you feel you can do,'” Shelton said. “There is no other option.”

Cord Blood Stem Cells Help Fight Juvenile Diabetes

To find a superior treatment for juvenile diabetes, scientists have turned to a young boy.

Seven years ago, when Liam was born, his parents Steven and Beth opted to store his umbilical cord blood as an insurance to treat potential future illness. Now that Liam has diabetes, doctors have been injecting stem cells taken from the umbilical cord blood to try and slow, or possibly even stop, the progress of his diabetes.

For the national pilot study at the University of Florida, there are seven other children undergoing similar transplants using stem cells from their own umbilical cords.

Patients with juvenile diabetes, if left untreated, can fall into a coma or suffer kidney failure. Insulin-producing cells in the pancreas are destroyed by this autoimmune disease. More than 1.5 million Americans, including 125,000 children are afflicted with juvenile diabetes. Also known as type 1 diabetes, there is no cure for this disease.

Cancer and dozens of other blood disorders are regularly treated using stem cells taken from cord blood. Easily stored in blood banks, the stem cell rich cord blood can be extracted from the umbilical cord minutes after a baby’s birth.

The lead doctor in the study spends much of his time of the phone cautioning parents about keeping their expectations realistic due to the anticipation the stem cells can be successful in fighting juvenile diabetes.

“It’s important not to destroy their hope,” said Dr. Michael, a pediatric endocrinologist. “Everybody wants to cure diabetes. But this is a pilot study. It’s unlikely to be the Holy Grail.”

But it has helped Liam. His body is now fighting off the progression of the disease. His blood glucose levels decreased after the infusion. Prior to being injected, doctors were saying he would need regular injections of insulin because his blood glucose levels were rising.

A urine test detected excessive glucose in his system back in December, soon after the test, he was diagnosed with diabetes. Insulin, a hormone that regulates the body’s metabolism of carbohydrates, including glucose, was still being produced by his body in small quantities. This early diagnosis and circumstance is often called the “honeymoon” phase of the disease.

“There’s no magic pill to stop the process,” said Liam’s father, Steven. “As parents, you feel you’re helpless. You see what’s happening to your child.”

Surfing the web late on a December night, Liam’s mother discovered the Florida stem cell study while researching juvenile diabetes. She thought back to when Liam was born and remembered the cord blood bank that she paid to store his umbilical cord blood.

She enrolled her son in the four-year clinical trial.

“We feel God was with us,” she said.

Before taking Liam for his transplant at the university in Gainesville, the family visited the Kennedy Space Center and Sea World as a treat.

“You’ve got to have some sugar with your medicine,” Steven said.

Liam received the stem cells in an intravenous infusion after having some blood drawn. The procedure took only half an hour to complete.

To avoid rejection, Liam’s own cord blood needed to be used. There is a chance of rejection even with stem cells from a parent or sibling.

The clinical trial intends to enroll a total of 10 or more children. Currently there are five girls and three boys, all between the ages of 3 and 7.

The study requires using all of a child’s cord blood. This fact may deter some families because if the child gets another disease there won’t be any cord blood left to use. This will most likely change however, as storage facilities improve freezing and thawing processes that tend to destroy cells, and also begin keeping cord blood in more than one vial. Other methods of producing and preserving cells may also emerge.

At a cost of roughly $1,500, taking blood from a cut umbilical cord takes only a few minutes. A blood storage fee of $100 a year generally applies as well. Storage has become increasingly popular since blood banks began storing cord blood in the past decade. Most decide on the option in case a child or relative becomes ill.

Opposed to cells extracted from bone marrow, cord blood stem cells have more potential to develop into specialized cells needed to help a body fight disease. They are also easier to obtain than bone marrow cells and less controversial compared to those cells taken from human embryos.

The study at the university seeks to stop the autoimmune process but, “to cure diabetes, cord blood stem cells may be combined in the future with other medications, such as immune suppressant drugs, in a mix similar to “cocktails” given to cancer and HIV patients,” Dr. Michael stated.

Meanwhile, Liam’s parents are thankful to be able to hold off on having to give their son’s insulin shots.

“Liam should be getting worse, not better,” Steven said.

“You’re happy about that, right?” said Liam.

“We’re absolutely happy,” said his father, a medical equipment sales and service engineer.

Causes of the disease include genetic predisposition and other factors such as viruses or being overweight. Of the three siblings, two have diabetes, but their father does not.

“We’re not saying this is the end-all,” Beth said. “But it gives people hope. That’s why stem cell research is so important.”

Blind Man Pins Hopes on Revolutionary Stem Cell Treatment

Lebers robbed 24-year-old Phil of his vision but he plans to have ground-breaking stem cell treatment to repair his eyesight. This will be the first treatment of its kind and if successful, Phil hopes it will let him see his fiancée Yvette for the first time in three years.

Phil has trouble making out colors and the world appears blurry most of the time due to the nerve damage the genetic condition has caused.

“It is a bit scary being the guinea pig for this,” said Phil.

“But ever since I found out this might be a way of getting my sight back, even if it just makes it a little better, I’ve been up for it.

“Doctors say that in theory it should work,” he added.

Just weeks after he started dating Yvette, the then 20-year-old Phil lost his eyesight overnight.

“We only started going out when he started having problems. But he hasn’t changed a bit,” said Yvette, the 23-year-old customer service worker.

“He has the same sense of humor and outlook on life. He’s incredible.”

Yvette added, “I’m worried about this treatment. But Phil faces the possibility of waking up with no sight as it is, so he really has nothing to lose. But whatever happens, I’ll love him for who he is. He’s my angel.”

During a night out with friends in May of 2003, Phil started to notice his eyesight was getting worse.

“Things were really blurry and I couldn’t make out people’s faces until they were really close to me. It was pretty terrifying. I went to the optician the next day. They said there was something wrong but did not know what and said I should go to hospital. I went to the Southern General in Glasgow and was admitted for two days for tests. I was petrified. I thought I might be dying. My mum, Trisha, died of a blood clot on her brain 12 years ago and I was terrified I had that,” said Phil.

Doctor’s determined that Phil was suffering from Lebers, a condition that affects only about 100 Scots, after conducting six months of tests.

“I’d never heard of it but I have found out it is a genetic illness passed on by a mother to her child,” stated Phil.

“In nine out of 10 cases it is sons who get it, and usually in their early 20s. So I was a classic case.”

In December, Phil will be traveling out of the country for the £10,000 pound stem cell treatment since it is not licensed in the UK. Phil heard of this particular clinic when a story broke that they had successfully treated individuals suffering from multiple sclerosis.

Thousands of stem cells taken from an umbilical cord will be injected into Phil’s body, half in his arm, a quarter in his left temple, and the final quarter in his right temple.

Having the potential to act as a “repair kit”, stem cells are the “building blocks” of the body and can turn into any tissue as well as copy themselves.

The clinic is one of only a handful in the world that presently carries out stem cell therapy.

Doctor’s at the clinic stated, “We’ve never treated this condition before. We could not give Phil any outcome data but could give him an assurance of safety. Stem cells have been shown to repair and regenerate nerve cells so we hope for success.”

“There is so much I want to do with my life and to do it the way I want to, I need to be able to see better. Doctors here say a cure for this in the UK is at least 15 years away.” added Phil. “I have to admit I’ll be totally gutted if it doesn’t work. I hope to have my sight back in time to see my nephew, Connor, open his Christmas presents. He’ll be 22 months and it’ll be the best present ever to see his wee face when he opens his parcels.”

As a result of the condition, Phil has had to adjust almost every single aspect of his life. Simple routines such as brushing his teeth, making a cup of coffee, or even getting dressed are becoming more and more complicated.

Watching football matches, reading, driving, are all now things of the past. Watching TV farther than a foot away from the screen is not possible, and even at a close distance, the picture is completely blurred. He even needs assistance from friends to help him buy the right products in the correct sizes when he goes shopping.

Phil refuses to let the illness get him down, even though the reality is that without treatment he could end up completely blind.

“I have good days and bad days, like anyone. But there is no point feeling sorry for myself. I am determined to get on with my life. I like to feel like everyone else and don’t like people feeling sorry for me,” said Phil.

Taking part in charity events, Phil has to raise all the cash to pay for the procedure.

“It has been a case of thinking of any way I can of getting people to donate. My friends and family have been a great support and I am getting there,” says Phil.

Without his fiancée Yvette, he says none of the fundraising would have been possible.

“She is my inspiration. She helped organize all the charity events and her positive attitude keeps me going. I’d be lost without her. I can’t wait for the day I can see her properly again and to watch her walk down the aisle. I’ll be the happiest man alive.”

One Giant Step, a Man with MS Hopes to Walk Again

Life was crushed for Chris, being diagnosed with MS five years ago; he has lost the use of his legs and is now in a wheelchair. But he has decided to fight his multiple sclerosis by arranging stem cell treatment, eager to reclaim the ability to walk. The 40 year old Chris now imagines playing football with his two young sons and later walking into a pub with them when they are older.

Leaving Chris incapable of walking, with deteriorating eyesight and the inability to control his bowel movements and bladder, the muscle-wasting disease took hold quickly.

After treatments were unsuccessful at the Hunters Moor Rehabilitation Centre in Newcastle, doctors told him there was no hope left.

Caretakers visit Chris’ adapted home, in Centenary Avenue, Harton, South Shields, several times per day; he needs to be hoisted out of bed every morning.

Taking 33 tablets a day to control the symptoms of MS, the daily mix is not his only worry as he was just diagnosed with diabetes this year.

After being accepted into a stem cell treatment program at a clinic in Holland, the thought that he may be able to walk again is the one thing keeping him going. After reading an article about a woman with MS who had regained the ability to walk after being treated at the same clinic in Holland, one of the caretakers told Butler about the clinic.

Chris, the former line manager, needs to raise 13,000 pounds to pay for the cost of the treatment which is still being researched in the UK.

The cost of accommodations and travel for him and two caretakers would take the figure closer to £20,000.

He said: “I can’t move anything from the waist down, and I’ve got pins and needles in my hands all the time. I used to cry and wonder ‘why me?’ I only kept going for my two little lads. I’ve got to keep my head up.”

“I want to walk. I want to be able to play football with my sons. I want to be able to take them for a pint when they are older,” said Chris.

“I know there’s a risk the treatment might not work – I’ve just got to hop,” he added.

He remains close to Kris, 12, and Stephen, nine, who live with their mum, although the illness has cost him his marriage.

Helping to regain movement, the cells restore damaged nerve transmitters and boost brain signals to the rest of the body say doctors. The treatment would consist of stem cells taken from umbilical cords being injected into Chris’ damaged cells.

Affecting more than 85,000 Britons, the cause of MS – the gradual degeneration of the nervous system – is still not fully understood.

$1 Million Gift for Stem Cell Research

The University of Rochester Medical Center just received the largest private donation ever from a Brighton couple to put toward stem cell research.

The couple, Jack (founder of Erdle Corp. in Henrietta) and Norma, did not indicate what variety of stem cell research the donated funds, an sum of $1 million dollars, should be used for.

Prior to Jack’s gift, UR had received some contributions towards stem cell research, but the quantity of donations were not many and each individually were not of a significant amount stated Peter.

Stem cells are the building block cells of all our organs and tissues.

The university inquired about the prospect of Jack contributing; so he went to his wife to see how she would like the money used. She quickly gave her answer.

The couple also donated $1 million to the Rochester Institute of Technology in 1998.

Jack’s company, which he started in the mid-1950’s, makes parts for electrical systems in computer, trains, and airplanes.

“I think there are so many diseases and sicknesses that could be helped with stem cell research — diabetes, Alzheimer’s, Parkinson’s, people who are paralyzed,” said Norma. “Just think how wonderful it would be, the lives we could save.”

The National Institutes of Health have given more than $40 million to The University of Rochester Medical Center to pursue stem cell research that may lead to cures for leukemia, multiple sclerosis, and spinal cord injury.

For the institute, the principal focus has been on animal and adult stem cell based research, as well as stem cells taken from umbilical cord blood due to the federal ban on funding new embryonic stem cell lines.

The NIH mandates that any federally funded programs share no resources with independently funded embryonic research, thus there is a possibility that the university may use a portion of the $1 million to produce the proper environment for research. Peter hopes the couple’s gift will encourage other philanthropists to also donate to stem cell research.

“Downstate medical centers have received millions,” Peter said about their stem cell donations, adding:

“It’s good Rochester is now in that company as result of Jack and Norma’s gift.”

Hope for Paraplegics, Stem Cell Therapy in India Delivers Results

Seven months of stem cell therapy has brought sensation back to a man who was left a paraplegic on December 26th, 2004, after his spinal cord was damaged during a road accident.

“Before operation, there was no sensation. Now I am feeling the sensation and am able to get up a bit on my own,” says 28-year-old man.

He is one of a dozen other people at the Global Hospitals in Hyderabad, India, who are undertaking stem cell therapy for spinal cord injury. The program is run under ICMR-approved protocol.

G.P.V. Subbaiah, who is an orthopedic and spinal surgeon, said that the result so far has been beyond his expectations. He was astonished by the display of such “encouraging results” in the 28-year-old patient. In January, the man was the first patient to be injected with adult-stem cells at the site of injury in the spinal cord.

Subbaiah said the patient had absolute loss of feeling from the chest downwards.

“Now he has regained all sensations, including light touch up to the groin. He also has increased sweating which is controlled by the autonomic nervous system. This shows that the system is also responding.”

Another accident victim from Saudi Arabia who flew to the hospital for stem cell treatment had regained some movement in his legs.

“Before the advent of the stem cell therapy, there was only supportive treatment to prevent bed sores and other problems like urinary infection,” said Dr. Subbaiah, “but now there is hope that some of the lost functions can be restored.”

Data from animal studies provide enough evidence that the therapy does work said the doctor.

Indian Spinal Injuries Center approximates that at least one lakh, or one-hundred thousand, spinal cord injuries happen each year. Due to the lack of proper data, this number may be grossly underestimated. Individuals from the age of 25 to 40 make up 85 to 90 percent of the spinal cord victims.

In their most productive years these injuries crippled them.

“It has a lot of impact on society,” he stated.

Skin Cells Show Potential to Grow Into Organs

Resembling an embryonic stem cell, a new pluripotent cell has been generated using a mouse skin cell by researchers at Kyoto University in Tokyo, Japan.

A U.S. scientific journal named Cell recently noted in their online issue that Prof. Shinya and Assistant Prof. Kazutoshi created a new pluripotent cell that has comparable characteristics as embryonic stem cells. This will give the new cell the capability to grow into organs and tissues just like embryonic cells. The professors named the new cell induced Pluripotent Stem, or iPS for short.

Extracted from an embryo, the use of the embryonic stem cell in medicine is ethically controversial. Since an embryo is not involved, the iPS cells would purge any ethical concerns. Although the new cells are derived from mouse skin cells, the future may bring the emergence of human iPS cells.

Adult-stem cell therapy has shown its effectiveness, but the thought of converting adult stem cells and making them function similar to embryonic stem cells would open even larger doors for treating patients. Individuals undergoing transplants could have new organs with identical genes as their own. There would be no immune response clearing the issue of post operative rejection, and also, no ethical dilemma.

The group speculated that amid the important gene factors in an embryonic stem cell, there should be a number that can reprogram somatic cells and induce pluripotency that are characteristic to the factors in an embryonic stem cell in early development.

Taking a skin cell extracted from a mouse tail, the researchers picked up 24 candidate gene factors and implanted four of those gene factors, including Sox2, into the selected skin cell and cultivated it.

Taking on a comparable pattern to embryonic stem cells after only two weeks, the skin cell with the four gene factors changed.

In three weeks, the new iPS cells formed tumors called teratomas containing nerves, digestive tissues and cartilage after it was reintroduced to the mouse body. The cell also developed heart muscle cells and nerves, and displayed signs of a pulse on a culture dish. This would validate the cells pluripotency.

iPS cells can be created without involving a generative cell using this method.

Yamanaka said, “We’ll continue the research and try to make iPS cells from human skin cells, and then be able to offer regenerative medical treatment using the cell.”

“It’s been considered impossible to create an ES cell from a somatic cell without using cloning technology, but (Shinya’s group) succeeded in generating a cell similar to an ES cell from a mouse somatic cell. This brought hopes that the same technique could be applied to human cells,” stated Teruhiko a team leader of Riken Center for Developmental Biology.

He added, “Regenerative medicine will definitely make progress in this direction in the future.”

Adult Stem Cell Therapy Holds Great Promise for Man with Ailing Heart

Richard has congestive heart failure. This disease affects his heart’s ability to pump sufficient blood to suit the body’s daily needs. Ultimately, the disease will progress to the point where the heart becomes weaker and weaker to a point of failure. That is why on August 16th, Richard a Braselton resident, and his wife Terre will fly to Thailand to receive stem cell therapy in Bangkok.

“I’m just weak, tired, and short of breath all the time,” Richard said. “I constantly have to monitor my blood pressure and my heart rate. All the medications, there’s no end to it.”

Outside of prescribing blood pressure medications, Richard’s doctors told him that there was nothing they could do when he was diagnosed in January. Angered by the lack of options they were presented with, Richard and Terre began to explore alternative treatment options. Their search finally concluded in Thailand, where a Bangkok-based biotechnology company will provide treatment for Richard using a relatively new medical procedure, utilizing adult stem cell therapy.

Richard’s own stem cells will be multiplied after doctors extract cells form a half pint of Richard’s blood. Later, doctors will take the newly multiplied stem cells and re-inject them into Richard’s ailing heart. He should experience less chest pain and greater strength in his daily living once the cells start to take effect, about a month or two following the procedure.

After performing the procedure on over 120 patients over a period of two years, the company claims a success rate of 80 percent. 11Alive, Paul Harvey, and the 700-Club have all joined in support of the treatment, touting “miracle” recoveries on their respective programs. The company’s website has these video news segments available for individuals to watch online as well as news of patients testifying before the congress about the benefits of adult stem cell therapy.

All this and there is still a poor understanding about the technicalities behind stem-cell led repair. Researchers see a result but question the process after stem cell are injected into an injured area of the body.

Adult stem cells hold the most potential at the present time. The course that future research will take has much to do with the ethical clash that is occurring over the use of embryos. The issue has now left the floor of the congress and has entered the lives of average people.

For Richard and Terre, the very fact that stem cells work trumped the need to know what manner the cells actually work in.

The advice that Richard should focus primarily on keeping his blood pressure down did not make neither him nor his wife very happy.

“We just didn’t expect that answer, that there’s nothing we can do,” Terre said. “This is just not an option for us.”

Terre began looking into the program in Bangkok after a family member heard of the treatment and told her. She spoke with several patients of the company along with a few company representatives after looking over the website. Later she learned that one of her co-workers knew someone who had successfully received treatment as well.

Three months ago, Richard was accepted into the program. Once they reach Bangkok, they will stay there for 20 days to tour the area before and after the procedure. The couple will pay $32,500 in cash for the “medical tourism” trip; this will cover the expenses completely minus the price of airfare.

They feel comfortable that they know enough about the non-US based company and stem cell therapy stated Terre.

“There’s no downside to this,” Terre said. “We don’t have any questions, we don’t have any concerns. We realize there are risks, but with an 80-percent rate of success, it’s a risk worth taking” (20-percent of those receiving the therapy experience no change — positive or negative — in their condition).

“I’ve got nothing to lose,” Richard says. “Rather than live a bad life like I’m living and doing nothing, I’d rather take chance and get something done.”

“It’s not a lot of money,” Terre says, noting that the price is “a really minimal cost when you’re talking about saving a life.” “A lot of people who are sick and trying to exercise other options are going to be able to find that money.”

“It’s costly, but it’s worth your life, I guess,” Richard said.

Impressed by the new technology, particularly the advancement in adult stem cell treatment, Richard and Terre are optimistic about the future of adult stem cell therapy.

“It’s going to be the coming way of medicine,” said Richard. “It’s gotta be, because it’s pretty strong.”

“This could eradicate cancer,” Terre said. “It is my personal opinion; the future of medicine is going to be stem cells. There’s no doubt in my mind.”

The company performing the procedure on Richard claims that once the stem cells are placed in the area of the heart that they, “have the potential to build new blood vessels and heart muscle.”

The theory is that the stem cells improve blood flow to the heart by regenerating or “revascularizing” functional blood vessels. The cells may also act as “scaffolds” which offer mechanical strength to the heart at a occasion when it is weak, or even promote the heart to release chemicals for repairing itself.

The jury is till out on how the stem cells help, but only vast potential seems to exist says Dr. Samuel, a cardiologist with Emory University. A major advantage of the therapy is that the patient receives his own cells, thus negating any type of immune response that could neutralize the therapeutic benefits of treatment making it less effective. Future research will lead to the transfer of adult stem cells from one body to another. This would allow for immediate injection at hospitals that would keep stem cells ready.

Presently in the United States, only clinical trials are permitted, but in five years the treatments “could definitely be translated into a pure clinical product,” states Samuel.

The couple commented on their opinions about embryoinc versus adult stem cells. With no ethical dilemma, adult stem cells hold great potential alone and thus they both choose to promote adult stem cell therapy as opposed to embryonic.

“My opinion is the American public is not educated,” Terre said. “These are your own stem cells; this is your own blood.”

“If we could just get over the hump of educating all Americans. It could be their son or daughter’s lives that we could save.”