February 18, 2013 by

MS Radio – Stem cells can change our lives

On Tuesday, February 19th, 2013
at 5pm EST

Stem Cells Change Lives
Click here to Listen Online

or Call (347) 327-9317
Toll Free (877) 497-9936

Join us on Multiple Sclerosis Radio as the Director of MSstation™ Radio Judi Lecoq and her panel of nine individuals candidly share their testimonies of living with Multiple Sclerosis and their experiences after undergoing Stem Cell Treatment.

 

Judi Lecoq

I was diagnosed with Secondary Progressive Multiple Sclerosis in 1997, and began the Stem Cell Journey, with Fundraising January 2010.

SammyJo Wilkinson

Diagnosed ’95 relapsing remitting MS, secondary progressed by 2002. May 2012 I had adult stem cells in Houston, TX

Jennifer Ziegler

I was diagnosed with MS in 2004. I started thinking about Adult Stem Cell Therapy around 6 yrs. ago.

Holly Huber

Diagnosed with Multiple Sclerosis in 2004. Within months of my official diagnosis, I couldn’t walk. I was quickly facing having to live the rest of my life in a wheelchair and needing to depend on someone else 24/7 for survival. After 9 months of clinical research, in 2008 I had my first stem cell treatment.

Fiona Sparrow

Diagnosed 2005 with RRMS in 2009. Then I was told I had Malignant MS an extremely aggressive form. Only 3-5% of patients have this form. In December 29/2011 I underwent a full bone marrow transplant/stem cell transplant!

Annette Williams

Diagnosed with Relapsing Remitting MS in 2008. In 2010 it progressed to secondary progressive. I heard about stem cell therapy and begin researching about it. Following a fund raiser I went and had adult stem cells.

Carla Hickman

Diagnosed in May of 2003 with Relapsing Remitting Multiple Sclerosis. I began looking into stem cells in 2009 and went to Costa Rica in 2010.

Kane Roper

Diagnosed with Multiple Sclerosis for roughly 7 – 8 years, before receiving stem cell treatment last Christmas.

Richard Humphries

In October of 2005 after several hundred tonic seizures, I was diagnosed with Relapsing Remitting Multiple Sclerosis. By March 2007, it transition to Secondary Progressive MS. My wife and I were looking at a wheelchair. By the time I chose to have his first Stem Cell Treatments in 2008, I was completely bedridden. My Stem Cell Journey is long and varied.

Preston Walker

Diagnosed on Dec. 2001 with RRMS. I went down for ASC treatment on May 2008, June of 2009 and July of 2010.

Filed Under: Adult Stem Cells, Multiple Sclerosis, Multiple Sclerosis, News, Stem Cell Research, Stem Cell Therapy Tagged With: , , , , ,
February 11, 2013 by

Allogeneic and autogolous stem cell therapy combined with physical rehabilitation: A case report on a chronically injured man with quadriplegia

Allogeneic and autogolous stem cell therapy combined with physical rehabilitation - A case report on a chronically injured man with quadriplegia

Daniel Leonard in Panama

This is a research paper written by Rebecca Johnston, Daniel Leonard’s sister. She recently graduated from a Physical Therapy degree program, and wrote her Capstone paper about Daniel’s stem cell therapy treatment in Panama.

Daniel is presented anonymously in the paper, but Rebecca and Daniel have given their permission for this paper to be shared. Daniel’s ASIA scores (pre and post treatment) are in the appendix of this paper.

 

Allogeneic and autogolous stem cell therapy combined with physical rehabilitation: A case report on a chronically injured man with quadriplegia

Abstract:

Background and Purpose: Stem cell therapy for SCI is a potentially promising treatment with increasing interest. This case report describes the use of a particular stem cell therapy protocol for a patient with chronic spinal cord injury, and describes his subsequent therapy and outcomes.

Case Description: The patient is a 29-year-old male who is chronically injured from a cervical spinal injury, resulting in quadriplegia. The patient was treated with a combined protocol of intrathecal (IT) and intravaneous (IV) allogeneic MSC and CD34+ cells and IT autologous BMMC at 6 ½ years post-injury. The results track the patient’s physical therapy progress until 6 months following stem cell treatment.

Outcomes: Recovery of strength in upper extremity and lower extremity muscle groups was noted, along with a functional increase in grip strength, ability to ambulate with assistance, and a significant decrease in daily medications.
Discussion: This case supports further investigation into treatment of chronically injured SCI patients with stem cell therapy followed by physical therapy.

Manuscript word count: 4321

A few highlights:

“After the patient underwent the stem cell treatment and returned to outpatient physical therapy in his hometown clinic in the United States, his MMT scores were tested over the period of 5 months post-stem cell treatment…. The patient did not decrease in strength in any of the muscles tested, and experienced improvements in 6/13 upper extremity muscle groups, and 8/9 lower extremity muscle groups.”

“The patient also had an increase in grip strength. His grip strength was measured by his occupational therapist to be 5 lbs on the right and 25 lbs on the left at one month before his stem cell treatment. Six months later, his grip strength was measured to be 22 lbs on the right and 36 lbs on the left. The patient reported that this increase in grip strength led to functional improvements, such as being able to self-catheterize, which he was completely unable to do since his injury.”

“The patient was also able to ambulate for the first time in 5 years at approximately 4 months after finishing his treatment. He was able to ambulate in partial weight bearing with the harness and max assist of two for 40 yards at .5 MPH.”

The original post on Daniel Leonard’s blog can be found here.

Filed Under: Adult Stem Cells, Bone Marrow, Cord Blood Stem Cells, News, Patient Stories, Spinal Cord Injury, Spinal Cord Injury, Spinal Cord Injury, Stem Cell Research, Stem Cell Therapy, Stem Cells Tagged With: , , , , , , , , , , , ,
February 6, 2013 by

Mesenchymal Stem Cells in Regenerative Medicine:Mechanisms of action, sources, and delivery options

Neil Riordan, PhD, Founder of the Stem Cell Institute in Panama City, Panama will be speaking today, Wednesday, Feb 6 at the STEMSO International Stem Cell Society 2013 Conference in Fort Lauderdale, FL.

The topic of Dr. Riordan’s discussion will be “Mesenchymal Stem Cells in Regenerative Medicine:Mechanisms of action, sources, and delivery options”

The theme for this year’s event is “Autologous Stem Cells: Who gets to decide…”

Filed Under: Adult Stem Cells, neil riordan, News, Stem Cell Research Tagged With: , , , , , , , , , ,
February 6, 2013 by

Multiple Sclerosis Radio – “Stem cells are your body’s natural healing mechanism” – Neil Riordan PhD

For anyone who missed Dr. Riordan’s talk on MS Radio yesterday, below is a link to the replay. Did you know that by age 30, 96% of the mesenchymal stem cells are gone from a person’s bone marrow? Why is MS a disease of the immune system? How can an automated machine analyze a sample of lecithin and buffer that contains no cells and show that it contains 10 million cells per ml? Tune in for these and more.

REPLAY: “Stem cells are your body’s natural healing mechanism” – Neil Riordan PhD

TODAY ON MULTIPLE SCLEROSIS RADIO!
Dr. Neil Riordan, Founder of Stem Cell Institute
Tuesday Feb 5, 2013 at 2 pm EST.

LISTEN ONLINE: Multiple Sclerosis Radio

or call in Join Us LIVE On Air
(347) 327-9317
or Toll-Free
(877) 497-9936

http://www.blogtalkradio.com/msradio/2013/02/05/stem-cells-your-bodys-natural-healing-mechanism-stem-kine-1

Filed Under: Adipose Stem Cells, Adult Stem Cells, Multiple Sclerosis, Multiple Sclerosis, News, Stem Cell Research, Stem Cell Therapy Tagged With: , , , , , , , ,
January 24, 2013 by

Liposuction method can adversely affect adipose tissue-derived stem cell yield and growth

Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure which was published in Cytotherapy (vol. 8 issue 2, 2006, pages 166-177)states that:

“Ultrasound-assisted liposuction resulted in a lower frequency of proliferating adult stem cells, as well as a longer population doubling time of adult stem cells, compared with resection…”

Those seeking adipose stem cell therapy should ask their doctor if he or she is using ultrasound assisted liposuction to collect the fat sample.

*Stem Cell Institute does not use ultrasound assisted liposuction.

Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure
M.J. Oedayrajsingh-Varma1, S.M. van Ham2, M. Knippenberg3, M.N. Helder4, J. Klein-Nulend3, T.E. Schouten5, M.J.P.F. Ritt1, F.J. van Milligen, PhD5,

1 Department of Plastic Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, the Netherlands
2 Department of Immunopathology, Sanquin Research at CLB, Amsterdam, the Netherlands
3 Department of Oral Cell Biology, ACTA-Vrije Universiteit, Amsterdam, the Netherlands
4 Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, the Netherlands
5 Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands
http://dx.doi.org/10.1080/14653240600621125, How to Cite or Link Using DOI
Permissions & Reprints

Filed Under: Adipose Stem Cells, liposuction, News, Stem Cell Research Tagged With: , , , , , , , ,
January 22, 2013 by

Patients beware: “Point of care” fat stem cell separation and counting kits inaccurate and not US FDA approved for humans.

An informative paper by Mary Pat Moyer, PhD detailing why “same-day” fat stem cell kits that are becoming more common in doctors’ offices across the US can miscount “stem cells” by large factors leading to over estimation of stem cell counts by as much as 20 times or more.

It also states, “no complete harvest and cell isolation systems have been approved by the FDA for autologous SVF harvest for immediate use [in humans].” These are just a couple of the arguments presented that demonstrate why it’s important to process adipose tissue properly in a professional lab setting.

Morrison DG, Hunt DA, Garza I, Johnson RA, Moyer MP*. Counting and Processing Methods Impact Accuracy of Adipose Stem Cell Doses. BioProcess J, 2012; 11(4): 4-17.

Filed Under: Adipose Stem Cells, Adult Stem Cells, News, Stem Cell Research Tagged With: , , , , , ,
January 14, 2013 by

Medistem Inc. Annual Letter to Shareholders

SAN DIEGO, CA–(Marketwire – Jan 4, 2013) – Medistem Inc. ( PINKSHEETS : MEDS ) today issues the following letter to shareholders.

Dear Fellow Shareholders,

2012 was marked by significant progress in the development of the Endometrial Regenerative Cell (ERC), our new universal donor “stem cell drug.” Most significantly, we initiated a double blind, placebo controlled clinical study in patients with end stage heart failure, in which ERC were administered via the Medistem’s patent-pending minimally invasive procedure. The clinical trial comprises three escalating doses of ERC with cohorts of 20 patients per dose. To date 14 patients have been treated with no adverse effects, thus demonstrating feasibility of the administration procedure, as well as safety of the cells. Because it is a double blind study, efficacy will not be known until the trial is completed. The clinical trial is being conducted at the Backulev Center for Cardiovascular Surgery in Moscow, Russia, by Academician Leo Bockeria. The company also initiated a 15 patient critical limb ischemia trial in China in collaboration with Shanghai Jia Fu Medical Apparatus Inc. To date two patients have been treated. The trial is based on the Medistem critical limb ischemia study that has been cleared by the FDA.

In addition, we licensed from Yale University the world-wide rights for a patent application using ERC to treat Type 1 diabetes. We also initiated a program in type 1 diabetes, with the goal of filing an Investigational New Drug application before the end of 2013 to allow for clinical trial initiation.

In 2012, researchers at the National Institutes of Health (NIH) independently verified and published a peer reviewed article confirming ERC possess a markedly higher expression of genes associated with new blood vessel formation and stem cell potency compared to bone marrow mesenchymal stem cells. The publication may be found at http://www.translational-medicine.com/content/pdf/1479-5876-10-207.pdf

In addition, our intellectual property was further enhanced with the issuance of patent #8,241,621 covering the use of fat derived stem cells for treatment of autoimmune conditions such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. We have also filed 2 patent applications covering the use of ERC for radiation protection and treatment of traumatic brain injury.

Also, in collaboration with several corporate and academic institutions we published a total of 7 peer reviewed papers in 2012 on collaborative breakthroughs we made in the areas of hepatitis, cancer, and prevention of transplant rejection.

Additionally, this year we added two new advisory board members including Gene Ray, Ph.D., and Alexander Gershman, M.D., Ph.D. Dr. Ray was founder of the Titan Corporation, where he served as CEO and a director of the corporation since the company’s inception in 1981. In 2011, Titan Corporation was acquired by L-3 Communications for $2.6 billion. Dr. Gershman is one of the first surgeons in the world to apply the method of laparoscopic surgery and robotic-assisted surgery to urology. He currently holds several hospital appointments, including: Director of Institute of Advanced Urology at the Cedars-Sinai Medical Center; Director of Urologic Laparoscopy in the Division of Urology, and Harbor-UCLA Medical Center.

Finally, this year marked a major transition in the leadership of the company. I was appointed to the position of CEO on October 26 and Dr. Thomas Ichim transitioned to the position of President and Chief Scientific Officer. Dr. Ichim has done an outstanding job leading the company for the past four years and I look forward to working closely with him at commercializing the ERC product.

In 2013 our objective will be to meet the following milestones:
•Return to “fully reporting” status and listing on the OTCBB
•Appointment of at least one new board member
•Initiation of the FDA cleared critical limb ischemia trial in the USA
•Completing enrollment in the RECOVER-ERC double blind cardiac trial
•Filing an IND for type 1 diabetes.

I want to end by thanking our loyal shareholders for their continued support as Medistem continues on its mission to generate the first practical “stem cell medicine.”

Sincerely Yours,

Dr. Alan Lewis
Chief Executive Officer
Medistem Inc.

About Medistem
Medistem Inc. is focused on the development of the Endometrial Regenerative Cell (ERC), a universal donor adult stem cell product. ERCs possess specialized abilities to stimulate new blood vessel growth and can differentiate into lung, liver, heart, brain, bone, cartilage, fat and pancreatic tissue. These unique properties have applications for treatment of critical limb ischemia (CLI), congestive heart failure (CHF), neurodegenerative diseases, liver failure, kidney failure, and diabetes. ERCs have been cleared by the FDA to begin studies in the United States.

ERCs have several distinguishing advantages to other stem cell therapies: a) Non-invasive method of collection; b) Unlimited supply of cells; isolated from menstrual blood of young healthy donors; c) Economical and scalable to manufacture; d) Exert higher therapeutic activity compared to other stem cells; and e) demonstrated safe in animal and pilot human studies.

Cautionary Statement
This press release does not constitute an offer to sell or a solicitation of an offer to buy any of our securities. This press release may contain certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking information. Factors which may cause actual results to differ from our forward-looking statements are discussed in our Form 10-K for the year ended December 31, 2007 as filed with the Securities and Exchange Commission.
.
.
Contact:.
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Thomas Ichim, Ph.D.
President and Chief Scientific Officer
Medistem Inc.
9255 Towne Centre Drive
Suite 450
San Diego, CA 92122
858 349 3617
www.medisteminc.com

Filed Under: medistem, News, Stem Cell Research Tagged With: , , , , ,
January 9, 2013 by

Jorge Paz MD: Adult Stem Cell Therapy for Arthritis, Sports Injury, and Autoimmune Disease || 3 of 3

Stem cell therapy for osteoarthritis using adipose (fat) stem cell. Case study of 76 year-old man with osteoarthritis in his knees. Stromal vasular fraction treatment statistics including side effects collected over 800 infusions. Stem cell treatments for sports injuries and why pro sports stars are seeking treatment. Case study of a professional dancer with knee and neck problems who returned to competition after stem cell treatment in Panama.

Filed Under: Arthritis, Jorge Paz MD, Stem Cell Lecture Videos, Uncategorized, Video - Stem Cell Therapy Tagged With: , , , , , , , , , ,
December 24, 2012 by

Stem cell therapy for spinal cord injury: Daniel Wiest

Filed Under: News, Patient Stories, Patient Testimonials, Spinal Cord Injury, Spinal Cord Injury, Spinal Cord Injury, Stem Cell Therapy, Video - Stem Cell Therapy Tagged With: , , , , , , , , , , ,
December 6, 2012 by

Stem cell treatments for chronic fatigue syndrome: Susan Lucey

“First I must say I have been steadily getting better. Everyone notices it. My long distance friends have all commented on the vitality and clarity in my voice. So much is changing in my body for the better. I can’t thank the staff at the SCI enough for saving my life. And of course, my beloved Dr Cheney, who knew better than anyone how sick I was … I feel such gratitude.

I was slipping into dementia from severe and unremitting CFS. I was desperate for help and when Dr Cheney invited me to go there in May, in my heart I knew I was going to get my life back. I was so sick that almost any quality of life was gone for me and I either wanted to die or get better. I was at the end of my rope as I was in constant and unrelenting pain, slipping away with dementia and fully bed-bound and home bound for several years after being vibrantly alive, loving life as an artist and a professor at the University of Minnesota, mother, wife and lover of life.

“I’ve regained peristalsis after 13 yrs. No more falling! No more chest pain, no more visits to the ER! I wake up the each day full of energy, not crashed. Thank you from the bottom of my heart… “

Although I state very enthusiastically my improvements, I still have a way to go; but because the improvements have been so marked I feel like there has already been an amazing transformation. Here are some of the improvements:

  • Anyone who speaks to me on the phone comments on how well I sound. Lately, I have heard in my voice an “authority” and sense of articulation that I once had when I was a professor and artist. My brain is healing and I have energy everyday. I still must rest most days but I want to get up and begin to rebuild my life. Incipit Vita Nova- Here begins the new life! I feel inspired! Before stem cells, I spoke often in a whisper as my vocal cord were weak and I would quickly tire, slur my speech and need to stop talking as it would exhaust me. I easily crashed from less than 10 minutes of phone conversation.
  • Comments from friends regarding getting well- ”woo yaa! Susan, you are lucid!” “You are back!…”look at you, your cognitive function is so much better.” I hear these comments everyday.
  • I was able to titrate from 40 mg to 5 mg of Cortef shortly after my 2nd visit to Panama. Now I plan to titrate off Cortef completely. With that, the bloating and weight gain is finally coming off my body.
  • I’ve regained peristalsis after 13 yrs.
  • No more falling! My balance is good and am able to climb out of, for example, a bath tub – I’m getting stronger! Falling was a constant worry and I did eventually fall and break my back recently. That was the final straw and I developed PTSD. I feel less pain now in the area of the herniated discs and I wonder if the stem cells will repair such injuries . Falling was a constant worry for my husband, there was a sense that my feet were not connected to my brain. Now that worry is in the past.
  • No more chest pain, no more visits to the ER! (15 visits last year!)
  • Fat turning into muscle, I can now stand up from a sitting position without the help of my arms pressing me up. My family comments on my form transforming.
  • Overall, more resiliency, vitality and cognitive improvement.
  • I am able to organize. I’ve been able to declutter and organize much of the piles of paperwork and miscellanea that have been piling up for a decade. . CFS made organizing impossible for me. I’ve heard that this is not uncommon.
  • I now have the energy to stay focused for 2 – 4 hrs at a time sitting in a chair doing paperwork or some task ( I have not had the strength to sit in a chair for 5 – 6 yrs. I wake up the each day full of energy, not crashed. Although I do feel muscle and joint pain from moving and so still need pain meds. But the most important thing is I rarely crash. I can be modestly active every day.
  • Memory! Although not perfect (I believe in part due to morphine) I am so much better. I can remember combinations of numbers on the spot. I know what I did the day before, the week before and what is planned in the future. I can remember what I wanted to do from day to day.

I am able to feel inspired and that is carried through the day to the next and the next. No amount of occupational therapy with strategies to support my memory ever worked. It’s hard to explain how far gone I was. I was lost to myself and I think it was the most terribly painful part of my experience of CFS. Regaining myself did not begin until after I was home from the 2nd stem cell protocol. And I am certain I needed the 30 day MS Protocol. None of these brain problems improved the first time and I could feel I was on a slow and disappointing slide backwards.

I wanted to thank you for all you have done for the benefit of myself and my family. My daughter, who moved home to help me out, has tears well up in her eyes regularly when she sees me interact with her in ways I haven’t since she was 14. You have been a bright light in the dark and desperate days of severe CFS. Thank you from the bottom of my heart from me and from that of my beautiful family, Chris and Christina.”

– S.L.

Filed Under: Autoimmune Diseases, Chronic Fatique Syndrome, News, Patient Stories, Stem Cells, Uncategorized Tagged With: , , , , , ,
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